Mathematical biology and pharmacology models have a long and rich history in the fields of
medicine and physiology, impacting our understanding of disease mechanisms and the …

Computational models of signal transduction face challenges of scale below the resolution
of a single cell. Here, we organize these challenges around three key interfaces for …

Abstract Systems biology aims at creating mathematical models, ie, computational
reconstructions of biological systems and processes that will result in a new level of …

Systems biology is a comprehensive quantitative analysis of the manner in which all the
components of a biological system interact functionally over time. Such an analysis is …

Highlights•One gene-one disease paradigm rarely explains incomplete penetrance.•Cellular
systems of interacting molecules mediate genotype-to-phenotype relationships.•Protein …

A field known as Systems Biology is emerging, from roots in the molecular biology and
genomic biology revolutions—the succession of which has led biomedical scientists to …

Systems approaches have long been used in pharmacology to understand drug action at
the organ and organismal levels. The application of computational and experimental …

Modeling is an integral component of modern biology. In this chapter we look into the role of
the model, as it pertains to Systems Medicine, and the software that is required to instantiate …

Understanding the factors that influence human health and cause diseases has always
been one of the major driving forces of biological research. With the spectacular progresses …

Human physiology is an ensemble of various biological processes spanning from
intracellular molecular interactions to the whole body phenotypic response. Systems biology …