The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled
testing of vaccines and therapeutics and defining aspects of severe acute respiratory …

Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide
pandemic with high morbidity and mortality. Development of animal models that recapitulate …

ABSTRACT A comprehensive analysis and characterization of a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection model that mimics non-severe and severe …

COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We
previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV …

Preclinical mouse models that recapitulate some characteristics of coronavirus disease
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …

Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread
throughout the world, resulting in a global public health emergency. The lack of vaccine and …

Human ACE2 Human angiotensin converting enzyme 2 (hACE2) is the key cell attachment
and entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with …

The emergence of SARS-CoV-2 has created an international health crisis, and small animal
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …

Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease
would benefit from validated small animal models. Here, we show that transgenic mice …

Abstract Coronavirus disease 2019 (COVID-19) is a declared pandemic that is spreading all
over the world at a dreadfully fast rate. Severe acute respiratory syndrome coronavirus-2 …