Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), initially termed 2019-new
CoV (2019-nCoV), is a novel coronavirus responsible for the severe respiratory illness …

In December 2019, the first cases of a new contagious disease were diagnosed in the city of
Wuhan, the capital of Hubei province in China. Within a short period of time the outbreak …

In late 2019, an outbreak of a severe respiratory disease caused by an emerging
coronavirus, SARS-CoV-2, resulted in high morbidity and mortality in infected humans …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that
has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a …

The acute respiratory distress syndrome (ARDS) is a common complication of severe COVID-
19 (coronavirus disease 2019) caused by SARS-CoV-2 (severe acute respiratory syndrome …

ABSTRACT World Health Organization has declared the ongoing outbreak of coronavirus
disease 2019 (COVID-19) a Public Health Emergency of International Concern. The virus …

Animal models recapitulating human COVID-19 disease, especially severe disease, are
urgently needed to understand pathogenesis and to evaluate candidate vaccines and …

ABSTRACT SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), is
suspected to have been first contracted via animal-human interactions; it has further spread …

The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We
generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures …

Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …