Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH …
FF Silveira, JO de Souza, LVB Hoelz… - European Journal of …, 2021 - Elsevier
In this work, we designed and synthesized 35 new triazolopyrimidine, pyrazolopyrimidine
and quinoline derivatives as P. falciparum inhibitors (3D7 strain). Thirty compounds …
and quinoline derivatives as P. falciparum inhibitors (3D7 strain). Thirty compounds …
Evaluation of 7-arylaminopyrazolo [1, 5-a] pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors
LFSP Azeredo, JP Coutinho, VAP Jabor… - European Journal of …, 2017 - Elsevier
Malaria remains one of the most serious global infectious diseases. An important target for
antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium …
antimalarial chemotherapy is the enzyme dihydroorotate dehydrogenase from Plasmodium …
The development of novel compounds against malaria: quinolines, triazolpyridines, pyrazolopyridines and pyrazolopyrimidines
L CS Pinheiro, L M. Feitosa, M O. Gandi, F F. Silveira… - Molecules, 2019 - mdpi.com
Based on medicinal chemistry tools, new compounds for malaria treatment were designed.
The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine …
The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine …
Identification of 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate …
ED Hartuti, T Sakura, MSO Tagod, E Yoshida… - International Journal of …, 2021 - mdpi.com
Plasmodium falciparum's resistance to available antimalarial drugs highlights the need for
the development of novel drugs. Pyrimidine de novo biosynthesis is a validated drug target …
the development of novel drugs. Pyrimidine de novo biosynthesis is a validated drug target …
Synthesis and Evaluation of Antiparasitic Activities of New 4-[5-(4-Phenoxyphenyl)-2H-pyrazol-3-yl]morpholine Derivatives
S Kuettel, A Zambon, M Kaiser, R Brun… - Journal of medicinal …, 2007 - ACS Publications
A series of new 4-[5-(4-phenoxyphenyl)-2 H-pyrazol-3-yl] morpholine derivatives, prepared
by two synthetic routes, were in vitro assayed against three Trypanosoma strains …
by two synthetic routes, were in vitro assayed against three Trypanosoma strains …
Biological activity of 1, 2, 3-triazole-2-amino-1, 4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control
RMC Souza, LMLM Pimentel, LKM Ferreira… - European journal of …, 2023 - Elsevier
Malaria can be caused by several Plasmodium species and the development of an effective
vaccine is challenging. Currently, the most effective tool to control the disease is the …
vaccine is challenging. Currently, the most effective tool to control the disease is the …
Identification of novel PfDHODH inhibitors as antimalarial agents via pharmacophore-based virtual screening followed by molecular docking and in vivo antimalarial …
Plasmodium falciparum dihydroorotate dehydrogenase (Pf DHODH) catalyses the fourth
reaction of de novo pyrimidine biosynthesis in parasites, and represents an important target …
reaction of de novo pyrimidine biosynthesis in parasites, and represents an important target …
In silico screening, synthesis, and antimalarial evaluation of PABA substituted 1, 3, 5-triazine derivatives as Pf-DHFR inhibitors
A Saha, AAK Choudhury, N Adhikari, SK Ghosh… - Experimental …, 2023 - Elsevier
Objectives Drug resistance in malaria parasites necessitates the development of new
antimalarial drugs with unique mechanisms of action. In the present research work, the …
antimalarial drugs with unique mechanisms of action. In the present research work, the …
Synthesis and evaluation of naphthyl bearing 1, 2, 3-triazole analogs as antiplasmodial agents, cytotoxicity and docking studies
S Balabadra, MK Kotni, V Manga, AD Allanki… - Bioorganic & Medicinal …, 2017 - Elsevier
Novel series of naphthyl bearing 1, 2, 3-triazoles (4a–t) were synthesized and evaluated for
their in vitro antiplasmodial activity against pyrimethamine (Pyr)-sensitive and resistant …
their in vitro antiplasmodial activity against pyrimethamine (Pyr)-sensitive and resistant …
New quinoline-5, 8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain
We report on the design, synthesis, and in vitro evaluation of new quinoline-5, 8-dione and
hydroxynaphthoquinone derivatives. The synthesized compounds were evaluated for in vitro …
hydroxynaphthoquinone derivatives. The synthesized compounds were evaluated for in vitro …