Virtual screening assisted discovery of novel natural products to inhibit the catalytic mechanism of Mycobacterium tuberculosis InhA
The pandemic prevalence of tuberculosis (TB) caused by increasing drug-resistant
Mycobacterium tuberculosis (Mtb) strains has posed severe global health threats. The …
Mycobacterium tuberculosis (Mtb) strains has posed severe global health threats. The …
Identification of bioactive natural compounds as efficient inhibitors against Mycobacterium tuberculosis protein-targets: a molecular docking and molecular dynamics …
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), imposes a
significantly high morbidity threat to humans in both developed and developing nations. The …
significantly high morbidity threat to humans in both developed and developing nations. The …
Structure based virtual screening and discovery of novel inhibitors against FabD protein of Mycobacterium tuberculosis
S Sundararajan, K Karunakaran… - Journal of Biomolecular …, 2023 - Taylor & Francis
The highly flexible nature of Mycobacterium tuberculosis (Mtb) can be owed to its tough cell
wall and multiple gene interaction system which makes it resistant to frontline TB drugs …
wall and multiple gene interaction system which makes it resistant to frontline TB drugs …
Designing novel possible kinase inhibitor derivatives as therapeutics against Mycobacterium tuberculosis: An in silico study
M Shahbaaz, A Nkaule, A Christoffels - Scientific reports, 2019 - nature.com
Rv2984 is one of the polyphosphate kinases present in Mycobacterium tuberculosis
involved in the catalytic synthesis of inorganic polyphosphate, which plays an essential role …
involved in the catalytic synthesis of inorganic polyphosphate, which plays an essential role …
In silico analysis to identify potential antitubercular molecules in Morus alba through virtual screening and molecular dynamics simulations
A major obstacle in the treatment of tuberculosis (TB) is to combat the emerging resistant
strains of its causing agent ie Mycobacterium tuberculosis (MTb). The emergence of …
strains of its causing agent ie Mycobacterium tuberculosis (MTb). The emergence of …
Elucidation of marine fungi derived anthraquinones as mycobacterial mycolic acid synthesis inhibitors: an in silico approach
Tuberculosis (TB) is a leading cause of mortality amongst infectious diseases. While the anti-
TB drugs can cure TB, the non-compliance and rapidly increasing resistance is of serious …
TB drugs can cure TB, the non-compliance and rapidly increasing resistance is of serious …
Pharmacophore model-based virtual screening, docking, biological evaluation and molecular dynamics simulations for inhibitors discovery against α-tryptophan …
Discovery of new anti-tuberculosis drugs with novel mode of action is urgently needed. The
tryptophan synthase is a genetically validated enzyme that catalyzes last step of tryptophan …
tryptophan synthase is a genetically validated enzyme that catalyzes last step of tryptophan …
Identification of new benzamide inhibitor against α-subunit of tryptophan synthase from Mycobacterium tuberculosis through structure-based virtual screening, anti …
Multi-drug-resistant tuberculosis and extensively drug-resistant tuberculosis has emerged as
global health threat, causing millions of deaths worldwide. Identification of new drug …
global health threat, causing millions of deaths worldwide. Identification of new drug …
In silico studies of alkaloids and their derivatives against N-acetyltransferase EIS protein from Mycobacterium tuberculosis
Antibiotic resistance against Mycobacterium tuberculosis (M. tb.) has been a significant
cause of death worldwide. The Enhanced intracellular survival (EIS) protein of the bacteria is …
cause of death worldwide. The Enhanced intracellular survival (EIS) protein of the bacteria is …
Binding thermodynamics and dissociation kinetics analysis uncover the key structural motifs of phenoxyphenol derivatives as the direct InhA inhibitors and the hotspot …
Given the current epidemic of multidrug-resistant tuberculosis, there is an urgent need to
develop new drugs to combat drug-resistant tuberculosis. Direct inhibitors of the InhA target …
develop new drugs to combat drug-resistant tuberculosis. Direct inhibitors of the InhA target …
相关搜索
- virtual screening mycobacterium tuberculosis
- virtual screening catalytic mechanism
- discovery of novel natural products
- virtual screening molecular dynamics
- virtual screening inhibitors discovery
- virtual screening benzamide inhibitor
- virtual screening biological evaluation
- virtual screening α tryptophan
- virtual screening silico analysis
- virtual screening tryptophan synthase
- virtual screening α subunit
- virtual screening morus alba
- hotspot residues inha inhibitors
- protein targets efficient inhibitors
- molecular dynamics mycobacterium tuberculosis
- inhibitors discovery mycobacterium tuberculosis