[HTML][HTML] SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

J Jansen, KC Reimer, JS Nagai, FS Varghese… - Cell stem cell, 2022 - cell.com
Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …

Human kidney spheroids and monolayers provide insights into SARS-CoV-2 renal interactions

D Omer, O Pleniceanu, Y Gnatek… - Journal of the …, 2021 - journals.lww.com
Background Although coronavirus disease 2019 (COVID-19) causes significan t morbidity,
mainly from pulmonary involvement, extrapulmonary symptoms are also major componen ts …

[HTML][HTML] Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations

L Helms, S Marchiano, IB Stanaway, TY Hsiang… - JCI insight, 2021 - ncbi.nlm.nih.gov
Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection
remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited …

Long COVID and kidney disease

S Yende, CR Parikh - Nature Reviews Nephrology, 2021 - nature.com
Kidney involvement is common in patients with acute SARS-CoV-2 infection, and subclinical
inflammation and injury may persist for many months, resulting in a progressive decline in …

SARS-CoV-2 causes acute kidney injury by directly infecting renal tubules

Z Chen, J Hu, L Liu, R Chen, M Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Acute kidney injury (AKI) is one of the most prevalent complications among hospitalized
coronavirus disease 2019 (COVID-19) patients. Here, we aim to investigate the causes, risk …

Is the kidney a target of SARS-CoV-2?

MA Martinez-Rojas, O Vega-Vega… - American Journal of …, 2020 - journals.physiology.org
The new disease produced by severe acute respiratory syndrome-coronavirus 2 (SARS-
CoV-2) represents a major pandemic event nowadays. Since its origin in China in …

Ultrastructural evidence for direct renal infection with SARS-CoV-2

EA Farkash, AM Wilson, JM Jentzen - Journal of the American …, 2020 - journals.lww.com
Background A significant fraction of patients with coronavirus disease 2019 (COVID-19)
display abnormalities in renal function. Retrospective studies of patients hospitalized with …

COVID-19 and the kidney: what we think we know so far and what we don't

SS Farouk, E Fiaccadori, P Cravedi, KN Campbell - Journal of nephrology, 2020 - Springer
The novel coronavirus disease infection (COVID-19) outbreak that was declared a global
pandemic in March 2020 had led to an internationally variable but concerning incidence of …

Kidney involvement in COVID-19 and rationale for extracorporeal therapies

C Ronco, T Reis - Nature Reviews Nephrology, 2020 - nature.com
The prevalence of direct kidney involvement in novel coronavirus disease (COVID-19) is
low, but such involvement is a marker of multiple organ dysfunction and severe disease …

COVID-19 and the kidneys: an update

C Benedetti, M Waldman, G Zaza, LV Riella… - Frontiers in …, 2020 - frontiersin.org
The new coronavirus disease 2019 (COVID-19) has become a world health emergency. The
disease predominantly effects individuals between 30 and 79 years of age with 81% of …