Improvement, scaling-up, and downstream analysis of exosome production

D Jafari, S Malih, M Eini, R Jafari… - Critical reviews in …, 2020 - Taylor & Francis
Exosomes are the most researched extracellular vesicles. In many biological, physiological,
and pathological studies, they have been identified as suitable candidates for treatment and …

Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

X Li, AL Corbett, E Taatizadeh, N Tasnim, JP Little… - APL …, 2019 - pubs.aip.org
ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …

[HTML][HTML] Current strategies for promoting the large-scale production of exosomes

Q Qu, B Fu, Y Long, ZY Liu, XH Tian - Current Neuropharmacology, 2023 - ncbi.nlm.nih.gov
Exosomes, as nanoscale biological vesicles, have been shown to have great potential for
biomedical applications. However, the low yield of exosomes limits their application. In this …

[PDF][PDF] Platform technologies and human cell lines for the production of therapeutic exosomes

J Kim, Y Song, CH Park, C Choi… - Extracell. Vesicles Circ …, 2021 - researchgate.net
Exosomes are extracellular vesicles secreted by most cell types and represent various
biological properties depending on their producing cells. They are also known to be …

Possibility of exosome-based therapeutics and challenges in production of exosomes eligible for therapeutic application

T Yamashita, Y Takahashi, Y Takakura - … and Pharmaceutical Bulletin, 2018 - jstage.jst.go.jp
Exosomes are cell-derived vesicles with a diameter 30–120 nm. Exosomes contain
endogenous proteins and nucleic acids; delivery of these molecules to exosome-recipient …

Exosome manufacturing status

W Whitford, P Guterstam - Future medicinal chemistry, 2019 - Taylor & Francis
Exosomes are secreted by mammalian cells and are widely distributed in cellular systems.
They are a medium of information and material transmission. The complexity of exosome …

Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022 - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

Exosome subpopulations: the isolation and the functions in diseases

X Ma, Z Chen, W Chen, Z Chen, X Meng - Gene, 2023 - Elsevier
Exosomes are nanoscale extracellular vesicles secreted by cells. Exosomes mediate
intercellular communication by releasing their bioactive contents (eg, DNAs, RNAs, lipids …

Engineered exosomes: a promising vehicle in cancer therapy

F Pooresmaeil, S Andi, B Hasannejad-Asl… - Therapeutic …, 2023 - Taylor & Francis
During the past few decades, researchers have attempted to discover an effective treatment
for cancer. Exosomes are natural nanovesicles released by various cells and play a role in …

[HTML][HTML] A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy

J Li, Y Zhang, PY Dong, GM Yang… - Biomedicine & …, 2023 - Elsevier
All forms of life produce nanosized extracellular vesicles called exosomes, which are
enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and …