[HTML][HTML] Blood-brain barrier: from physiology to disease and back

MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Blood-brain barrier: more contributor to disruption of central nervous system homeostasis than victim in neurological disorders

M Xiao, ZJ Xiao, B Yang, Z Lan, F Fang - Frontiers in Neuroscience, 2020 - frontiersin.org
The blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular
system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by …

The molecular constituents of the blood–brain barrier

BW Chow, C Gu - Trends in neurosciences, 2015 - cell.com
The blood–brain barrier (BBB) maintains the optimal microenvironment in the central
nervous system (CNS) for proper brain function. The BBB comprises specialized CNS …

The blood–brain barrier in health and disease

R Daneman - Annals of neurology, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …

Blood-brain barrier dysfunction in CNS disorders and putative therapeutic targets: an overview

SR Archie, A Al Shoyaib, L Cucullo - Pharmaceutics, 2021 - mdpi.com
The blood-brain barrier (BBB) is a fundamental component of the central nervous system
(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain …

Establishment and dysfunction of the blood-brain barrier

Z Zhao, AR Nelson, C Betsholtz, BV Zlokovic - Cell, 2015 - cell.com
Structural and functional brain connectivity, synaptic activity, and information processing
require highly coordinated signal transduction between different cell types within the …

Development, maintenance and disruption of the blood-brain barrier

B Obermeier, R Daneman, RM Ransohoff - Nature medicine, 2013 - nature.com
The interface between the blood circulation and the neural tissue features unique
characteristics that are encompassed by the term'blood-brain barrier'(BBB). The main …

Basic physiology of the blood-brain barrier in health and disease: a brief overview

M Kaya, B Ahishali - Tissue Barriers, 2021 - Taylor & Francis
The blood-brain barrier (BBB), a dynamic interface between blood and brain constituted
mainly by endothelial cells of brain microvessels, robustly restricts the entry of potentially …

The blood-brain barrier in health and chronic neurodegenerative disorders

BV Zlokovic - Neuron, 2008 - cell.com
The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

Pathophysiology of the blood–brain barrier: animal models and methods

BT Hawkins, RD Egleton - Current topics in developmental biology, 2007 - Elsevier
The specialized cerebral microvascular endothelium interacts with the cellular milieu of the
brain and extracellular matrix to form a neurovascular unit, one aspect of which is a …