The rat blood—brain barrier transcriptome

BE Enerson, LR Drewes - Journal of Cerebral Blood Flow & …, 2006 - journals.sagepub.com
The blood-brain barrier (BBB) is the cellular interface between the circulating blood and
neural environment, and is created by apposed endothelial cells and their intercellular tight …

Blood–brain barrier structure and function and the challenges for CNS drug delivery

NJ Abbott - Journal of inherited metabolic disease, 2013 - Springer
The neurons of the central nervous system (CNS) require precise control of their bathing
microenvironment for optimal function, and an important element in this control is the blood …

Glia-induced reversible disruption of blood–brain barrier integrity and neuropathological response of the neurovascular unit

CL Willis - Toxicologic pathology, 2011 - journals.sagepub.com
The blood–brain barrier (BBB) is the regulated interface that mediates selective transcellular
transport of nutrients and essential components from the blood into the brain parenchyma …

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

RN Munji, AL Soung, GA Weiner, F Sohet… - Nature …, 2019 - nature.com
Blood vessels in the CNS form a specialized and critical structure, the blood–brain barrier
(BBB). We present a resource to understand the molecular mechanisms that regulate BBB …

Blood–Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies

AE Alkhalifa, NF Al-Ghraiybah, J Odum… - International Journal of …, 2023 - mdpi.com
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

The blood-brain barrier and the inflammatory response

VH Perry, DC Anthony, SJ Bolton, HC Brown - Molecular medicine today, 1997 - cell.com
The environment of the brain is controlled by a sophisticated endothelial barrier that
prevents the free entry of solutes from the blood. It is commonly assumed that this blood …

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

H Kadry, B Noorani, L Cucullo - Fluids and Barriers of the CNS, 2020 - Springer
The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

Recent advances towards overcoming the blood–brain barrier

A Ali, MS Arshad, MA Khan, MW Chang, Z Ahmad - Drug Discovery Today, 2023 - Elsevier
The blood–brain barrier (BBB) is a protective element of the neurovascular unit (NVU)
surrounded by astrocytes, pericytes, extracellular matrix, and the tight junctional complex …

Blood–brain barrier and neurodegenerative diseases—modeling with iPSC-derived brain cells

YC Wu, TM Sonninen, S Peltonen, J Koistinaho… - International journal of …, 2021 - mdpi.com
The blood–brain barrier (BBB) regulates the delivery of oxygen and important nutrients to
the brain through active and passive transport and prevents neurotoxins from entering the …

From neurodevelopmental to neurodegenerative disorders: the vascular continuum

J Ouellette, B Lacoste - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …