Direct nose-to-brain drug delivery, a promising approach for treating neurological disorders,
faces challenges due to anatomical variations between adults and children. This study aims …

Purpose Aerosol particle deposition in the human nasal cavity is of high interest in particular
for intranasal central nervous system (CNS) drug delivery via the olfactory cleft. The …

Background: Targeting drugs to the olfactory region in the nasal cavity can bypass the
restrictive blood–brain barrier and enhance their direct delivery to the brain. However …

Purpose Nose-to-brain drug administration along the olfactory and trigeminal nerve
pathways offers an alternative route for the treatment of central nervous system (CNS) …

Intranasal administration of drugs serves as a promising, noninvasive option for the
treatment of various disorders of the central nervous system and upper respiratory tract …

The nasal epithelium is an important target for drug delivery to the nose and secondary
organs such as the brain via the olfactory bulb. For both topical and brain delivery, the …

Successful delivery of drugs to the Olfactory region (OR) is the key to treating diseases
through the nasal cavity. The purpose of this paper is to investigate the effect of auxiliary …

The present work examines regional deposition within the nose for nasal sprays over a large
and wide ranging parameter space by using numerical simulation. A set of 7 realistic adult …

Abstract Central Nervous System (CNS) disorders are one of the major causes of fatalities in
the world today. Thus, it is essential to transport a considerable amount of drugs to a specific …

Objective: The nasal cavity effectively captures the particles present in inhaled air, thereby
preventing harmful and toxic pollutants from reaching the lungs. This filtering ability of the …