BACKGROUND Molecular characterization in pediatric papillary thyroid cancer (PTC),
distinct from adult PTC, is important for developing molecularly targeted therapies for …

PURPOSE In 2014, data from a comprehensive multiplatform analysis of 496 adult papillary
thyroid cancer samples reported by The Cancer Genome Atlas project suggested that …

Background: Pediatric papillary thyroid carcinoma (PTC) is a rare malignancy, but with
increasing incidence. Pediatric PTCs have distinct clinical and pathological features and …

BACKGROUND An increase in thyroid cancers, predominantly papillary thyroid carcinoma
(PTC), has been recently reported in children. METHODS The histopathology of 28 …

Context Pediatric differentiated thyroid cancer (DTC) differs from adult DTC in its underlying
genetics and clinicopathological features. In this report, we studied these aspects in 48 …

Context Distant metastases (DM) from childhood differentiated thyroid carcinoma (DTC) are
uncommon and published studies are limited. Objective This work aimed to describe the …

Background Thyroid carcinoma, which is rare in pediatric patients (age 0–18 years) but
more common in adolescent and young adult (AYA) patients (age 15–39 years), carries the …

Background Larotrectinib is a first-in-class, central nervous system-active, highly selective
tropomyosin receptor kinase (TRK) inhibitor approved by the EMA and FDA for the treatment …

The aim of this study was to test the hypothesis that our 60-gene DNA/RNA ThyroSeq v2
next-generation sequence (NGS) assay would identify additional genetic markers, including …

Background: Previous studies reported significant differences in the clinical presentation
and outcomes of papillary thyroid carcinoma (PTC) in pediatric patients compared with …