The COVID-19 pandemic, caused by SARS-CoV-2 infection, remains a dramatic threat to
human life and economic well-being worldwide. Significant heterogeneity in the severity of …

NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …

The coronavirus disease 2019 (COVID-19) global pandemic, caused by severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been marked by severe cases …

Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …

Dysregulated immune response is the key factor leading to unfavorable coronavirus disease
2019 (COVID-19) outcome. Depending on the pathogen-associated molecular pattern, the …

SARS-CoV-2 might directly activate NLRP3 inflammasome resulting in an endogenous
adjuvant activity necessary to mount a proper adaptive immune response against the virus …

Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate
inflammation and viral infection, but their effects on severe acute respiratory syndrome …

Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …

Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …