S100B expression in and effects on microglia

C Adami, G Sorci, E Blasi, AL Agneletti, F Bistoni… - Glia, 2001 - Wiley Online Library
We evaluated the intracellular and extracellular biological role of S100B protein with respect
to microglia. S100B, which belongs to the multigenic family of Ca2+‐binding proteins, is …

S100B proteins that lack one or both cysteine residues can induce inflammatory responses in astrocytes and microglia

T Koppal, AGM Lam, L Guo, LJ Van Eldik - Neurochemistry international, 2001 - Elsevier
The astrocytic protein S100B stimulates neurite outgrowth and neuronal survival during CNS
development. S100B can also stimulate glial activation, leading to induction of pro …

Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures

TV Petrova, J Hu, LJ Van Eldik - Brain research, 2000 - Elsevier
The astrocyte-derived protein S100B stimulates production of inducible nitric oxide synthase
and nitric oxide (NO) in astrocytes [Hu et al., 1996, J. Biol. Chem. 271: 2543], but its effect on …

S100B in brain damage and neurodegeneration

M Rothermundt, M Peters, JHM Prehn… - … research and technique, 2003 - Wiley Online Library
S100B is a calcium‐binding peptide produced mainly by astrocytes that exert paracrine and
autocrine effects on neurons and glia. Some knowledge has been acquired from in vitro and …

S100B in neuropathologic states: the CRP of the brain?

J Sen, A Belli - Journal of neuroscience research, 2007 - Wiley Online Library
In recent years there has been a proliferation of interest in the brain‐specific protein S100B,
its many physiologic roles, and its behaviour in various neuropathologic conditions. Since …

Extracellular S100B protein modulates ERK in astrocyte cultures

DS Gonçalves, G Lenz, J Karl, CA Gonçalves… - …, 2000 - journals.lww.com
S100B is a calcium binding protein expressed and secreted by astrocytes. Extracellular
S100B stimulates the proliferation of astroglial cells and the survival of neurons …

S100β induces neuronal cell death through nitric oxide release from astrocytes

J Hu, A Ferreira, LJ Van Eldik - Journal of neurochemistry, 1997 - Wiley Online Library
The glial‐derived neurotrophic protein S100β has been implicated in the development and
maintenance of the nervous system. S100β has also been postulated to play a role in …

The S100B protein in biological fluids: more than a lifelong biomarker of brain distress

F Michetti, V Corvino, MC Geloso… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 644–659. Abstract S100B is a calcium‐binding protein
concentrated in glial cells, although it has also been detected in definite extra‐neural cell …

Growing role of S100B protein as a putative therapeutic target for neurological-and nonneurological-disorders

F Michetti, G Di Sante, ME Clementi… - Neuroscience & …, 2021 - Elsevier
S100B is a calcium-binding protein mainly expressed by astrocytes, but also localized in
other definite neural and extra-neural cell types. While its presence in biological fluids is …

S100 protein expression in subpopulations of neurons of rat brain

M Rickmann, JR Wolff - Neuroscience, 1995 - Elsevier
Available data are conflicting as regards the occurrence of Ca2+ and Zn2+ binding S100
proteins in neurons of mammalian brain. Here the localization and expression of S100 was …