Accumulation of raft lipids in T‐cell plasma membrane domains engaged in TCR signalling
Activating stimuli for T lymphocytes are transmitted through plasma membrane domains that
form at T‐cell antigen receptor (TCR) signalling foci. Here, we determined the molecular …
form at T‐cell antigen receptor (TCR) signalling foci. Here, we determined the molecular …
Selective accumulation of raft-associated membrane protein LAT in T cell receptor signaling assemblies
T Harder, M Kuhn - The Journal of cell biology, 2000 - rupress.org
Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate
the assembly of signaling protein complexes. Moreover, cholesterol-sphingolipid raft …
the assembly of signaling protein complexes. Moreover, cholesterol-sphingolipid raft …
Lipid raft domains and protein networks in T-cell receptor signal transduction
T Harder - Current opinion in immunology, 2004 - Elsevier
Activation of the T-cell antigen receptor (TCR) is a key event in triggering the physiological
responses of T lymphocytes to antigen. The earliest TCR-evoked signalling steps, such as …
responses of T lymphocytes to antigen. The earliest TCR-evoked signalling steps, such as …
Lipid rafts in T cell receptor signalling
PS Kabouridis - Molecular membrane biology, 2006 - Taylor & Francis
The molecular events and the protein components that are involved in signalling by the T
cell receptor (TCR) for antigen have been extensively studied. Activation of signalling …
cell receptor (TCR) for antigen have been extensively studied. Activation of signalling …
Lipid rafts and the initiation of T cell receptor signaling
HT He, A Lellouch, D Marguet - Seminars in immunology, 2005 - Elsevier
The role of lipid rafts in T cell signalling has recently been extensively studied and hotly
debated. In this review we wish to present recent advances in the study of lipid rafts with …
debated. In this review we wish to present recent advances in the study of lipid rafts with …
The role of lipid rafts in T cell antigen receptor (TCR) signalling
Copyright 2000 Academic PressPlasma membranes of many cell types contain domains
enriched in specific lipids and cholesterol, called lipid rafts. In T lymphocytes, key T cell …
enriched in specific lipids and cholesterol, called lipid rafts. In T lymphocytes, key T cell …
Plasma membrane segregation during T cell activation: probing the order of domains
T cell activation leads to a segregation of plasma membrane domains to form TCR signalling
clusters and eventually immunological synapses. At these T cell activation sites signalling …
clusters and eventually immunological synapses. At these T cell activation sites signalling …
Cutting edge: lipid raft integrity affects the efficiency of MHC class I tetramer binding and cell surface TCR arrangement on CD8+ T cells
DR Drake, TJ Braciale - The Journal of Immunology, 2001 - journals.aai.org
Physically distinct cholesterol/sphingolipid-rich plasma membrane microdomains, so-called
lipid rafts, have been recognized to play an important regulatory role in various cellular …
lipid rafts, have been recognized to play an important regulatory role in various cellular …
The T cell receptor resides in ordered plasma membrane nanodomains that aggregate upon patching of the receptor
J Dinic, A Riehl, J Adler, I Parmryd - Scientific reports, 2015 - nature.com
Two related models for T cell signalling initiation suggest either that T cell receptor (TCR)
engagement leads to its recruitment to ordered membrane domains, often referred to as lipid …
engagement leads to its recruitment to ordered membrane domains, often referred to as lipid …
The amplification of TCR signaling by dynamic membrane microdomains
A Viola - Trends in Immunology, 2001 - cell.com
Modulation of T-cell receptor (TCR) signaling is essential for the regulation of T-cell
responses to infectious agents. Recently, many laboratories have suggested that TCR …
responses to infectious agents. Recently, many laboratories have suggested that TCR …