Targeting NSP-13 protein of SARS CoV-2 with selected natural compounds: An in-silico approach
D Sharma, AR Gill, P Bansal… - Journal of Applied …, 2024 - journals.ansfoundation.org
SARS-CoV-2 swiftly spread in Wuhan, China, leading to a pandemic crisis worldwide.
Genome sequence analysis of this virus revealed a close analogy with its closely related …
Genome sequence analysis of this virus revealed a close analogy with its closely related …
[HTML][HTML] A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein
DR Littler, M Liu, JL McAuley, SA Lowery… - Journal of Biological …, 2021 - ASBMB
The Nsp9 replicase is a conserved coronaviral protein that acts as an essential accessory
component of the multi-subunit viral replication/transcription complex. Nsp9 is the …
component of the multi-subunit viral replication/transcription complex. Nsp9 is the …
[HTML][HTML] Structure-based inhibitor screening of natural products against NSP15 of SARS-CoV-2 revealed thymopentin and oleuropein as potent inhibitors
R Vijayan, S Gourinath - Journal of proteins and proteomics, 2021 - Springer
Coronaviruses are enveloped, non-segmented positive-sense RNA viruses with the largest
genome among RNA viruses. Their genome contains a large replicase ORF which encodes …
genome among RNA viruses. Their genome contains a large replicase ORF which encodes …
Abrogating the nsp10–nsp16 switching mechanisms in SARS-CoV-2 by phytochemicals from Withania somnifera: a molecular dynamics study
The search for therapeutic small molecules and vaccines for Covid-19 treatment is an urgent
but evolving topic. The virus has claimed over 3,782,490 lives (as of 12 June 2021), with the …
but evolving topic. The virus has claimed over 3,782,490 lives (as of 12 June 2021), with the …
Virtual Development of COVID-19 Drugs Targeting Nsp16-Nsp10 Complex
K Wang, H Yang, L Tang - Journal of Student Research, 2023 - jsr.org
The search for pharmaceutical treatment for COVID-19 has been progressive. Currently
approved medicines include therapeutic antibodies and antiviral drugs. However, the …
approved medicines include therapeutic antibodies and antiviral drugs. However, the …
Discovery of Anti-SARS-CoV-2 Nsp9 Binders from Natural Products by a Native Mass Spectrometry Approach
The search for effective antiviral agents against SARS-CoV-2 remains a critical global
endeavor. In this study, we focused on the viral nucleocapsid protein Nsp9, which is a key …
endeavor. In this study, we focused on the viral nucleocapsid protein Nsp9, which is a key …
[HTML][HTML] The nsp15 nuclease as a good target to combat SARS-CoV-2: mechanism of action and its inactivation with FDA-approved drugs
M Saramago, VG Costa, CS Souza, C Bárria… - Microorganisms, 2022 - mdpi.com
The pandemic caused by SARS-CoV-2 is not over yet, despite all the efforts from the
scientific community. Vaccination is a crucial weapon to fight this virus; however, we still …
scientific community. Vaccination is a crucial weapon to fight this virus; however, we still …
Targeting the vital non-structural proteins (NSP12, NSP7, NSP8 and NSP3) from SARS-CoV-2 and inhibition of RNA polymerase by natural bioactive compound …
E Aleebrahim-Dehkordi, H Ghoshouni… - Journal of Molecular …, 2023 - Elsevier
The prevalence of SARS-CoV-2-induced respiratory infections is now a major challenge
worldwide. There is currently no specific antiviral drug to prevent or treat this disease …
worldwide. There is currently no specific antiviral drug to prevent or treat this disease …
Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian Medicinal Plants as promising inhibitory agents against SARS-CoV-2 …
Background Since the index case was reported in China, COVID-19 has led to the death of
at least 4 million people globally. Although there are some vaccine cocktails in circulation …
at least 4 million people globally. Although there are some vaccine cocktails in circulation …
[HTML][HTML] Investigation of protein-protein interactions and hotspot region on the NSP7-NSP8 binding site in NSP12 of SARS-CoV-2
JX Lima Neto, KS Bezerra, ED Barbosa… - Frontiers in molecular …, 2024 - frontiersin.org
Background: The RNA-dependent RNA polymerase (RdRp) complex, essential in viral
transcription and replication, is a key target for antiviral therapeutics. The core unit of RdRp …
transcription and replication, is a key target for antiviral therapeutics. The core unit of RdRp …