Ligand fishing approach to explore Amaryllidaceae alkaloids as potential antiviral candidates targeting SARS-CoV-2 Nsp4
DK Yonamine, VEN Dos Reis, AE Feu… - … of Pharmaceutical and …, 2024 - Elsevier
Ligand fishing, also described as affinity-based assay, represents a convenient and efficient
approach to separate potential ligands from complex matrixes or chemical libraries. This …
approach to separate potential ligands from complex matrixes or chemical libraries. This …
Identifying inhibitors of NSP16-NSP10 of SARS-CoV-2 from large databases
The COVID-19 pandemic, which has already claimed millions of lives, continues to pose a
serious threat to human health, requiring the development of new effective drugs. Non …
serious threat to human health, requiring the development of new effective drugs. Non …
In Vitro and In Vivo Therapeutic Potential of 6,6′-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea on Cells and K18-hACE2 Mice Infected with SARS-CoV-2
S Weiss, K Waidha, S Rajendran… - International Journal of …, 2023 - mdpi.com
We have previously published research on the anti-viral properties of an alkaloid mixture
extracted from Nuphar lutea, the major components of the partially purified mixture found by …
extracted from Nuphar lutea, the major components of the partially purified mixture found by …
Identification of potential target endoribonuclease NSP15 inhibitors of SARS‐COV‐2 from natural products through high‐throughput virtual screening and molecular …
LC Hu, CH Ding, HY Li, ZZ Li, Y Chen… - Journal of Food …, 2022 - Wiley Online Library
SARS‐CoV‐2 wreaks havoc around the world, triggering the COVID‐19 pandemic. It has
been confirmed that the endoribonuclease NSP15 is crucial to the viral replication, and thus …
been confirmed that the endoribonuclease NSP15 is crucial to the viral replication, and thus …
[HTML][HTML] Nigella sativa L as a potential phytotherapy for coronavirus disease 2019: A mini review of in silico studies
AE Koshak, EA Koshak - Current Therapeutic Research, 2020 - Elsevier
Background Coronaviruses are responsible for several human diseases, such as the
infectious novel coronavirus disease 2019 (COVID-19), which is caused by severe acute …
infectious novel coronavirus disease 2019 (COVID-19), which is caused by severe acute …
Structural-Based Virtual Screening of FDA-Approved Drugs Repository for NSP16 Inhibitors, Essential for SARS-COV-2 Invasion Into Host Cells: Elucidation From MM …
NSP16 is one of the structural proteins of the severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) necessary for its entrance to the host cells. It exhibits 2'O-methyl …
2 (SARS-CoV-2) necessary for its entrance to the host cells. It exhibits 2'O-methyl …
Cytotoxicity and Multi-Enzyme Inhibition of Nepenthes miranda Stem Extract on H838 Human Non-Small Cell Lung Cancer Cells and RPA32, Elastase, Tyrosinase …
CY Lee, YC Chen, YH Huang, Y Lien, CY Huang - Plants, 2024 - mdpi.com
The carnivorous pitcher plants of the genus Nepenthes have long been known for their
ethnobotanical applications. In this study, we prepared various extracts from the pitcher …
ethnobotanical applications. In this study, we prepared various extracts from the pitcher …
Identification of naphthyridine and quinoline derivatives as potential Nsp16-Nsp10 inhibitors: a pharmacoinformatics study
This research is a recent effort to explore some new heterocyclic compounds as novel and
potential nonstructural protein-16-nonstructural protein-10 (Nsp16-Nsp10) inhibitors for the …
potential nonstructural protein-16-nonstructural protein-10 (Nsp16-Nsp10) inhibitors for the …
In silico investigations of the multi‐targeted antiviral potential of small molecule phytochemicals of Nelumbo nucifera Gaertn. seed extracts against SARS‐CoV‐2 for …
The therapeutics of COVID‐2 was significantly obtained from nutraceutical approaches
based on traditional knowledges and long practices. The current study was aimed to …
based on traditional knowledges and long practices. The current study was aimed to …
Inhibition of nonstructural protein 15 of SARS‐CoV‐2 by golden spice: A computational insight
R Singh, VK Bhardwaj, R Purohit - Cell biochemistry and …, 2022 - Wiley Online Library
The quick widespread of the coronavirus and speedy upsurge in the tally of cases demand
the fast development of effective drugs. The uridine‐directed endoribonuclease activity of …
the fast development of effective drugs. The uridine‐directed endoribonuclease activity of …