[HTML][HTML] Inhibition of SARS–CoV–2 NSP–15 by Uridine–5′–Monophosphate Analogues Using QSAR Modelling, Molecular Dynamics Simulations, and Free Energy …
MM Alshahrani - Saudi Pharmaceutical Journal, 2024 - Elsevier
SARS–CoV–2 is accountable for severe social and economic disruption around the world
causing COVID–19. Non–structural protein–15 (NSP15) possesses a domain that is vital to …
causing COVID–19. Non–structural protein–15 (NSP15) possesses a domain that is vital to …
[HTML][HTML] Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and …
Background and aim The ongoing global pandemic due to SARS-CoV-2 caused a medical
emergency. Since December 2019, the COVID-19 disease is spread across the globe …
emergency. Since December 2019, the COVID-19 disease is spread across the globe …
Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9
DR Littler, B Mohanty, SA Lowery, RN Colson… - Journal of Biological …, 2021 - ASBMB
The coronaviral nonstructural protein 9 (Nsp9) is essential for viral replication; it is the
primary substrate of Nsp12's pseudokinase domain within the viral replication transcription …
primary substrate of Nsp12's pseudokinase domain within the viral replication transcription …
Development of the Novel Nsp16 Inhibitors as Potential Anti-SARS-CoV-2 Agents
K Zhang, AV Sulimov, IS Ilin, DC Kutov… - Supercomputing …, 2024 - superfri.org
Computer aided structural based approach was used to find inhibitors of SARS-CoV-2
nsp16 (2'-O-methyltransferase). Docking based virtual screening of three libraries, Enamine …
nsp16 (2'-O-methyltransferase). Docking based virtual screening of three libraries, Enamine …
Development of Pan-Anti-SARS-CoV-2 Agents through Allosteric Inhibition of nsp14/nsp10 Complex
SARS-CoV-2 nsp14 functions both as an exoribonuclease (ExoN) together with its critical
cofactor nsp10 and as an S-adenosyl methionine-dependent (guanine-N7) …
cofactor nsp10 and as an S-adenosyl methionine-dependent (guanine-N7) …
Identification of persuasive antiviral natural compounds for COVID-19 by targeting endoribonuclease NSP15: A structural-bioinformatics approach
SARS-CoV-2 is a positive-stranded RNA virus that bundles its genomic material as
messenger-sense RNA in infectious virions and replicates these genomes through RNA …
messenger-sense RNA in infectious virions and replicates these genomes through RNA …
Targeting SARS-coV-2 non-structural proteins
D Tam, AC Lorenzo-Leal, LR Hernández… - International Journal of …, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped
respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly …
respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly …
Coronavirus inhibitors targeting nsp16
EA Omer, S Abdelfatah, M Riedl, C Meesters… - Molecules, 2023 - mdpi.com
During the past three decades, humans have been confronted with different new
coronavirus outbreaks. Since the end of the year 2019, COVID-19 threatens the world as a …
coronavirus outbreaks. Since the end of the year 2019, COVID-19 threatens the world as a …
Peptide inhibitors derived from the nsp7 and nsp8 cofactors of nsp12 targeting different substrate binding sites of nsp12 of the SARS-CoV-2
SARS-COV-2 is responsible for the COVID-19 pandemic, which has infected more than 767
million people worldwide including about 7 million deaths till 5 June 2023. Despite the …
million people worldwide including about 7 million deaths till 5 June 2023. Despite the …
Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16
F Kozielski, C Sele, VO Talibov, J Lou, D Dong… - RSC Chemical …, 2022 - pubs.rsc.org
Since the emergence of SARS-CoV-2 in 2019, Covid-19 has developed into a serious threat
to our health, social and economic systems. Although vaccines have been developed in a …
to our health, social and economic systems. Although vaccines have been developed in a …