In embryonic stem cells (ESCs), the Tip60 histone acetyltransferase activates genes
required for proliferation and silences genes that promote differentiation. Here we show that …

Histone deacetylases 1 and 2 (HDAC1/2) form the core catalytic components of corepressor
complexes that modulate gene expression. In most cell types, deletion of both Hdac1 and …

Epigenetic regulation of gene expression is important in maintaining self-renewal of
embryonic stem (ES) and trophoblast stem (TS) cells. Histone deacetylases (HDACs) …

Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate
chromatin structure as the core catalytic components of corepressor complexes. Although …

Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is
known about their function in mammalian development. HDAC1 was implicated previously …

Histone acetylation and deacetylation correlate with diverse biological phenomena through
gene transcription. Histone deacetylases (HDACs) regulate deacetylation of histones and …

The maintenance of the resident adult neural stem/progenitor cell (NSPC) pool depends on
the precise balance of proliferation, differentiation, and maintenance of the undifferentiated …

Background Tip60 is a key histone acetyltransferase (HAT) enzyme that plays a central role
in diverse biological processes critical for general cell function; however, the chromatin …

Histone deacetylases (HDACs) are important determinants of gene transcription and other
biological processes. HDAC11 is one of the least characterized HDACs and is the only …

In eukaryotic cells, covalent modifications to core histones contribute to the establishment
and maintenance of cellular phenotype via regulation of gene expression. Histone …