Genetically engineered mice have provided much information about gene function in the
field of developmental biology. Recently, conditional gene targeting using the Cre/loxP …

Branching morphogenesis, mesenchymal cell condensation and mesenchymal-to-epithelial
conversion are key steps in kidney development and morphogenesis of several other …

In Mammals, kidney development proceeds in three stages (reviewed in 1). The first two
stages lead to the formation of transient structures, the pronephros and the mesonephros …

With the advent of gene-targeting in mouse embryonic stem (ES) cells, the use of knockout
mice to study the physiological effects of loss of gene function has become increasingly …

Background: Kidney diseases are worldwide public health problems with a high cost and
increasing incidence. By revealing the genetic and cellular mechanism behind mammalian …

The development of the mammalian kidney is a complex and in part unknown process which
requires interactions between pluripotential/stem cells, undifferentiated mesenchymal cells …

The metanephric, or definitive, kidney forms as a result of inductive processes between
tissues of two distinct embryologic orgins, the metanephric mesenchymal blastema and the …

The kidney is a model developmental system for understanding mesodermal patterning and
organogenesis, a process that requires regional specification along multiple body axes, the …

Conditional gene targeting utilising the Cre/loxP system, which allows spatial and temporal
control of gene expression, has been increasingly used to study gene function in vivo. The …

Abnormalities of kidney and urinary tract development are the most common cause of end-
stage kidney failure in childhood in the United States. Over the past 20 years, the advent of …