▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

Eukaryotic DNA is packaged into a nucleoprotein structure known as chromatin, which is
comprised of DNA, histones, and nonhistone proteins. Chromatin structure is highly …

Genetic information is packaged in the highly dynamic nucleoprotein structure called
chromatin. Many biological processes are regulated via post-translational modifications of …

The enzyme‐catalyzed acetylation of the N‐terminal tail domains of core histones provides a
rich potential source of epigenetic information. This may be used both to mediate transient …

Histone acetylation is closely linked to gene transcription. The identification of histone
acetyltransferases (HATs) and the large multiprotein complexes in which they reside has …

Although histone acetylation has historically been linked to transcription activation, recent
studies indicate that this modification and the enzymes that catalyze it have much broader …

Post-translational acetylation of the core histone amino-terminal tails has long been
associated with both chromatin assembly and the regulation of gene expression. The recent …

Modification of histone amino terminal tails by acetylation has long been linked to the
transcriptional capacity of genes in chromatin and to various aspects of chromatin dynamics …

Histone acetylation acts as a landmark and determinant for chromatin function. Active roles
in the transcription and assembly of chromatin have been discovered for histone …

Histone acetylation is an important regulatory mechanism that controls transcription and
diverse nuclear processes. While great progress has been made in understanding how …