Stably enhanced histone acetylation has long been regarded as a condition of
transcriptionally active genes. Recent papers suggest a more dynamic model, with rapid …

The nuclear matrix, the RNA-protein skeleton of the nucleus, has a role in the organization
and function of nuclear DNA. Nuclear processes associated with the nuclear matrix include …

Histone acetylation and phosphorylation destablizes nucleosome and chromatin structure.
Relaxation of the chromatin fiber facilitates transcription. Coactivator complexes with histone …

Histone acetyltransferases (HATs) directly link chromatin modification to gene activation.
Recent structure/function studies provide insights into HAT catalysis and histone binding …

There are several enzymes, acetylases and deacetylases, that can regulate transcription by
modifying the acetylation state of histones or other promoter-bound transcription factors …

In the nucleus, DNA is tightly packaged into higher-order structures, generating an
environment that is highly repressive towards DNA processes such as gene transcription …

The flexible N-terminal tails of core histones are subject to dynamic, reversible lysine
acetylation. At least 10 histone deacetylases have been identified in Saccharomyces …

The acetylation of the core histone N-terminal “tail” domains is now recognized as a highly
conserved mechanism for regulating chromatin functional states. The following article …

Alteration of chromatin is central to genomic regulation. Chromatin is composed of
nucleosomes which are particles consisting of DNA in association with an octamer of two …

Core histone acetylation is a key prerequisite for chromatin decondensation and plays a
pivotal role in regulation of chromatin structure, function and dynamics. The addition of …