We have isolated the predominant cytoplasmic histone acetyltransferase activity from
Saccharomyces cerevisiae. This enzyme acetylates the lysine at residue 12 of free histone …

Modifications of both DNA and chromatin can affect gene expression and lead to gene
silencing. Evidence of links between DNA methylation and histone hypoacetylation is …

Chromatin structure is gaining increasing attention as a potential target in the treatment of
cancer. Relaxation of the chromatin fiber facilitates transcription and is regulated by two …

Although a link between histone acetylation and transcription has been established, it is not
clear how acetylases function in the nucleus of the cell and how they access their targets in …

Hat1 is the sole known example of a type B histone acetyltransferase. While it has long been
presumed that type B histone acetyltransferases participate in the acetylation of newly …

The post-translational modification of histones plays an important role in chromatin
regulation, a process that insures the fidelity of gene expression and other DNA …

The functional capacity of genetically encoded histone proteins can be powerfully expanded
by posttranslational modification. A growing body of biochemical and genetic evidence …

Histone posttranslational modifications and chromatin dynamics are inextricably linked to
eukaryotic gene expression. Among the many modifications that have been characterized …

It is more evident now than ever that nucleosomes can transmit epigenetic information from
one cell generation to the next. It has been demonstrated during the past decade that the …

Since the first report of p53 as a non-histone target of a histone acetyltransferase (HAT),
there has been a rapid proliferation in the description of new non-histone targets of HATs. Of …