Adverse effects of levamisole in cocaine users: a review and risk assessment

TM Brunt, J van den Berg, E Pennings, B Venhuis - Archives of Toxicology, 2017 - Springer
The immunomodulatory adjuvant and antihelminth levamisole is increasingly used as an
adulterant in cocaine worldwide. An accumulating body of clinical and toxicological literature …

Levamisole in cocaine: unexpected news from an old acquaintance

A Larocque, RS Hoffman - Clinical Toxicology, 2012 - Taylor & Francis
Levamisole is a pharmaceutical with anthelminthic and immunomodulatory properties that
was previously used in both animals and humans to treat inflammatory conditions and …

Agranulocytosis and other consequences due to use of illicit cocaine contaminated with levamisole

JA Buchanan, EJ Lavonas - Current opinion in hematology, 2012 - journals.lww.com
More than three fourths of cocaine users in the United States are exposed to levamisole; a
significant minority of these individuals will develop autoimmune-mediated neutropenia …

Levamisole—a toxic adulterant in illicit drug preparations: a review

KM Midthun, LS Nelson, BK Logan - Therapeutic Drug Monitoring, 2021 - journals.lww.com
Discovered in the 1960s, the common anthelminthic levamisole has seen widespread use in
veterinary applications. Its use rapidly expanded thereafter to include human medical …

Detection of levamisole exposure in cocaine users by liquid chromatography-tandem mass spectrometry

KL Lynch, SS Dominy, J Graf… - Journal of analytical …, 2011 - academic.oup.com
Levamisole, a veterinary antihelminthic, was recently recognized as an adulterant in cocaine
and is known to cause severe adverse reactions in some cocaine users. Because of the …

Levamisole-adulterated cocaine: what about in European countries?

C Eiden, C Diot, O Mathieu, M Mallaret… - … of Psychoactive Drugs, 2014 - Taylor & Francis
Background: A wide variety of somatic complications is reported or expected among cocaine
users because of the adulterant levamisole. Most of the reports come from North America …

Levamisole-adulterated cocaine: two fatal case reports and evaluation of possible cocaine toxicity potentiation

F Indorato, G Romano, N Barbera - Forensic science international, 2016 - Elsevier
Levamisole has been identified as a cocaine adulterant in the United States since 2002.
Although there is a variation in the percentage of levamisole in cocaine samples between …

Complications associated with use of levamisole-contaminated cocaine: an emerging public health challenge

KC Lee, B Ladizinski, DG Federman - Mayo Clinic Proceedings, 2012 - Elsevier
Levamisole is an immunomodulatory agent that was used to treat various cancers before
being withdrawn from the United States market in 2000 because of adverse effects …

Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite (s) involvement

A Wolford, TS McDonald, H Eng, S Hansel… - Drug Metabolism and …, 2012 - ASPET
The United States Public Health Service Administration is alerting medical professionals that
a substantial percentage of cocaine imported into the United States is adulterated with …

Levamisole: a dangerous new cocaine adulterant

A Chang, J Osterloh, J Thomas - Clinical Pharmacology & …, 2010 - Wiley Online Library
Levamisole has increasingly been discovered in street cocaine as an adulterant. Recent
reports have linked levamisole in street cocaine to agranulocytosis in cocaine users. It is …