Camptothecin (CPT), a natural product and its synthetic derivatives exert potent anticancer
activity by selectively targeting DNA Topoisomerase I (Top1) enzyme. CPT and its clinically …

Abstract Synthesis of 4-(3, 5-dimethyl-1H-pyrazol-1-yl)-5, 6, 7, 8-tetrahydrobenzo [4, 5]
thieno [2, 3-d] pyrimidine 1 and its functionalized reactions as nucleophile with various …

Abstract Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy.
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …

A series of new pyrazole linked benzothiazole-β-naphthol derivatives were designed and
synthesized using a simple, efficient and ecofriendly route under catalyst-free conditions in …

Previous research studies confirm that molecules containing 1, 2, 3-triazole moiety are
potential anticancer agents which elevates effectiveness and reduces drug resistance …

The identification of novel Topoisomerase II (Topo II) inhibitors is one of the most attractive
directions in the field of bactericide research and development. In our ongoing efforts to …

Computational approaches represent valuable and essential tools in each step of the drug
discovery and development trajectory. Several computational methodologies are suitable to …

DNA topoisomerases comprise a major aspect of basic cellular biology and are molecular
targets for a variety of drugs like antibiotics, antibacterials and anticancer drugs. They act by …

Chemical diversification of type II topoisomerase (Topo II) inhibitors remains indispensable
to extend their anti-tumor therapeutic values which are limited by their side effects. Herein …

DNA topoisomerases comprise an important family of enzymes that catalyse the induction of
topological changes (eg relaxation/supercoiling, catenation/decatenation and …