Filoviruses are the causative agents of an increasing number of disease outbreaks in human
populations, including the current unprecedented Ebola virus disease (EVD) outbreak in …

Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other
filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report …

Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry
receptor for filoviruses. While previous studies focused on filovirus entry requirements of …

Ebolaviruses and marburgviruses belong to the Filoviridae family and often cause severe,
fatal hemorrhagic fever in humans and non-human primates. The magnitude of the 2014 …

Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic
fever in primates, with extremely high fatality rates. Studies have focused on elucidating how …

Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite
considerable efforts, no essential cellular receptors for filovirus entry have been identified …

Ebola virus (EBOV) entry requires internalization into host cells and extensive trafficking
through the endolysosomal network in order to reach late endosomal/lysosomal …

In human and non-human primates, filoviruses (Ebola and Marburg viruses) cause severe
hemorrhagic fever. Recently, other animals such as pigs and some species of fruit bats have …

Ebola virus (EboV) infection causes fatal haemorrhagic fever with mortality rates exceeding
75%. Owing to the lack of available vaccines or therapeutics, it presents a considerable …

Zaire Ebola virus (EBOV) is a zoonotic pathogen that causes severe hemorrhagic fever in
humans. A single viral glycoprotein (GP) mediates viral attachment and entry. Here, virus …