[HTML][HTML] Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein
S Duquerroy, A Vigouroux, PJM Rottier, FA Rey… - Virology, 2005 - Elsevier
The coronavirus spike glycoprotein is a class I membrane fusion protein with two
characteristic heptad repeat regions (HR1 and HR2) in its ectodomain. Here, we report the X …
characteristic heptad repeat regions (HR1 and HR2) in its ectodomain. Here, we report the X …
[HTML][HTML] Structural characterization of the SARS-coronavirus spike S fusion protein core
B Tripet, MW Howard, M Jobling, RK Holmes… - Journal of Biological …, 2004 - ASBMB
The spike (S) glycoprotein of coronaviruses mediates viral entry into host cells. It is a type 1
viral fusion protein that characteristically contains two heptad repeat regions, denoted HR-N …
viral fusion protein that characteristically contains two heptad repeat regions, denoted HR-N …
[HTML][HTML] Solution structure of the severe acute respiratory syndrome-coronavirus heptad repeat 2 domain in the prefusion state
S Hakansson-McReynolds, S Jiang, L Rong… - Journal of Biological …, 2006 - ASBMB
The envelope glycoprotein, termed the spike protein, of severe acute respiratory syndrome
coronavirus (SARS-CoV) is known to mediate viral entry. Similar to other class 1 viral fusion …
coronavirus (SARS-CoV) is known to mediate viral entry. Similar to other class 1 viral fusion …
A trimerizing GxxxG motif is uniquely inserted in the severe acute respiratory syndrome (SARS) coronavirus spike protein transmembrane domain
In an attempt to understand what distinguishes severe acute respiratory syndrome (SARS)
coronavirus (SCoV) from other members of the coronaviridae, we searched for elements that …
coronavirus (SCoV) from other members of the coronaviridae, we searched for elements that …
Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS‐CoV): In search of potent SARS‐CoV entry inhibitors
Severe acute respiratory coronavirus (SARS‐CoV) spike (S) glycoprotein fusion core
consists of a six‐helix bundle with the three C‐terminal heptad repeat (HR2) helices packed …
consists of a six‐helix bundle with the three C‐terminal heptad repeat (HR2) helices packed …
Tryptophan-dependent membrane interaction and heteromerization with the internal fusion peptide by the membrane proximal external region of SARS-CoV spike …
Y Liao, SM Zhang, TL Neo, JP Tam - Biochemistry, 2015 - ACS Publications
The spike (S) protein of severe acute respiratory syndrome-associated CoV (SARS-CoV)
mediates membrane fusion and viral entry. These events involve structural rearrangements …
mediates membrane fusion and viral entry. These events involve structural rearrangements …
[HTML][HTML] Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein
Y Deng, J Liu, Q Zheng, W Yong, M Lu - Structure, 2006 - cell.com
Entry of SARS coronavirus into its target cell requires large-scale structural transitions in the
viral spike (S) glycoprotein in order to induce fusion of the virus and cell membranes. Here …
viral spike (S) glycoprotein in order to induce fusion of the virus and cell membranes. Here …
Functional characterization of heptad repeat 1 and 2 mutants of the spike protein of severe acute respiratory syndrome coronavirus
WE Chan, CK Chuang, SH Yeh, MS Chang… - Journal of …, 2006 - Am Soc Microbiol
To understand the roles of heptad repeat 1 (HR1) and HR2 of the spike (S) protein of the
severe acute respiratory syndrome coronavirus (SARS-CoV) in virus-cell interactions, the …
severe acute respiratory syndrome coronavirus (SARS-CoV) in virus-cell interactions, the …
Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome …
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a newly emergent virus
responsible for a worldwide epidemic in 2003. The coronavirus spike proteins belong to …
responsible for a worldwide epidemic in 2003. The coronavirus spike proteins belong to …
A single tyrosine in the severe acute respiratory syndrome coronavirus membrane protein cytoplasmic tail is important for efficient interaction with spike protein
CE McBride, CE Machamer - Journal of virology, 2010 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes 3 major envelope
proteins: spike (S), membrane (M), and envelope (E). Previous work identified a dibasic …
proteins: spike (S), membrane (M), and envelope (E). Previous work identified a dibasic …