Recent studies have demonstrated the influence of clock genes in cell cycle regulation, cell
proliferation, apoptosis and DNA damage recognition and repair. There is evidence …

The clock gene machinery controls cellular metabolism, proliferation, and key functions,
such as DNA damage recognition and repair. Dysfunction of the circadian clock is involved …

Clock genes create a complicated molecular time-keeping system consisting of multiple
positive and negative feedback loops at transcriptional and translational levels. This …

Circadian rhythms are fundamental biological systems in most organisms. Epidemiological
and animal studies have demonstrated that disruption of circadian rhythms is linked to tumor …

Increasing evidence indicates that disruption of circadian rhythms may be directly linked to
cancer. Here we report that the expression levels of the core clock genes Per1 and Per3 …

Deregulated expression of clock gene per2 has previously been associated with
progression of cancer. The aim of the present study was to identify genes related to per2 …

Aim Experimental studies have shown that some circadian core clock genes may act as
tumour suppressors and have an important role in the response to oncological treatment …

The circadian timing system controls about 40% of the transcriptome and is important in the
regulation of a wide variety of biological processes including metabolic and proliferative …

Abstract Background and Objectives The circadian rhythm regulates the cell cycle
progression and DNA damage response. The aim of our study was to investigate the …

Wang Y, Cheng YS, Yu G, et al. Expression of PER, CRY, and TIM genes for the
pathological features of colorectal cancer patients. OncoTargets and Therapy. 2016; 9: 1997 …