Early goal-directed therapy modulates systemic inflammation and results in significant
reductions in morbidity, mortality, and healthcare resource consumption. Early goal-directed …

Research knowledge translation into clinical practice pathways is a complex process that is
often time‐consuming and resource‐intensive. Recent evidence suggests that the use of …

Objective To investigate the effect of early goal-directed therapy (EGDT) on treatment of
critical patients with severe sepsis/septic shock. Methods A multi-center, prospective …

Abstract The Surviving Sepsis Campaign guidelines for the management of severe sepsis
and septic shock recommend that the initial hemodynamic resuscitation be done according …

Objectives: Early goal-directed therapy has shown discordant survival outcomes in sepsis
studies. We aim to find the reasons for this discordance. Design: Random-effects and …

OBJECTIVE: The identification and treatment of critical illness is often initiated by emergency
medical services (EMS) providers. We hypothesized that emergency department (ED) …

Sepsis is common, often fatal and requires rapid interventions to improve outcomes. While
the optimal management of sepsis in the intensive care setting is the focus of extensive …

Background: Improved outcomes for severe sepsis and septic shock have been consistently
observed with implementation of early best practice intervention strategies or the 6-hour …

Background: Early goal-directed therapy might benefit patients with sepsis and septic shock
in Australia and New Zealand. However, the current treatment and outcome of these patients …

Objectives: To describe our experience with early goal‐directed therapy (EGDT),
corticosteroid administration, and recombinant human activated protein C (rhAPC) …