Exposure of lung tissues to cigarette smoke is a major cause of human disease and death
worldwide. Unfortunately, adequate model systems that can reliably recapitulate disease …

Smoking represents a major risk factor for chronic obstructive pulmonary disease (COPD),
but it is difficult to characterize smoke-induced injury responses under physiological …

Organs-on-chips are microfluidic cell culture devices created using microchip manufacturing
techniques that contain hollow microchannels lined by living cells, which recreate …

Respiratory diseases account for unprecedented mortality owing to a lack of personalized or
insufficient therapeutic interventions. Fostering pulmonary research into managing …

Here we describe a microphysiological system that replicates the functional unit of the living
human lung. This human “breathing lung-on-a-chip” microdevice provides unique …

The past years have witnessed concerted efforts across the respiratory community to
establish more relevant in vitro preclinical tools for pulmonary research [1-3]. A strong …

Abstract'Organs-on-chips' are microengineered biomimetic systems containing microfluidic
channels lined by living human cells, which replicate key functional units of living organs to …

Tissue engineering approaches, including those to functional lung tissues, are finely honed
by the inclusion of upgraded devices that mimic biophysical and biochemical features in …

The entire luminal surface of the lungs is populated with a complex yet confluent,
uninterrupted airway epithelium in conjunction with an extracellular liquid lining layer that …

Human organ-on-a-chip models are powerful tools for preclinical research that can be used
to study the mechanisms of disease and evaluate new targets for therapeutic intervention …