Epigenomic maps identify gene regulatory elements by their chromatin state. However,
prevailing short-read sequencing methods cannot effectively distinguish alleles, evaluate …

Igf2 and H19 are closely linked, reciprocally imprinted genes on mouse distal chromosome
7. The paternally expressed Igf2 encodes a potent fetal growth factor and the maternally …

Chromatin modifications are linked with regulating patterns of gene expression, but their
causal role and context-dependent impact on transcription remains unresolved. Here we …

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation
in all organisms. Genetic variation in regulatory regions has been connected with diseases …

Identification of functional, noncoding elements that regulate transcription in the context of
complex genomes is a major goal of modern biology. Localization of functionality to specific …

Abstract The Encyclopedia of DNA Elements (ENCODE) project has established a genomic
resource for mammalian development, profiling a diverse panel of mouse tissues at 8 …

With hundreds of epigenomic maps, the opportunity arises to exploit the correlated nature of
epigenetic signals, across both marks and samples, for large-scale prediction of additional …

Chromatin profiling at locus resolution uncovers gene regulatory features that define cell
types and developmental trajectories, but it remains challenging to map and compare …

Genomic imprinting is implicated in the control of gene dosage in neurogenic niches. Here
we address the importance of Igf2 imprinting for murine adult neurogenesis in the …

Studies of genome regulation routinely use high-throughput DNA sequencing approaches to
determine where specific proteins interact with DNA, and they rely on DNA amplification and …