Background There is now convincing evidence that pleiotropy across the genome
contributes to the correlation between human traits and comorbidity of diseases. The recent …

Genetic prediction of common complex disease risk is an essential component of precision
medicine. Currently, genome-wide association studies (GWASs) are mostly composed of …

Polygenic risk scores are emerging as a potentially powerful tool to predict future
phenotypes of target individuals, typically using unrelated individuals, thereby devaluing …

An important task of human genetics studies is to predict accurately disease risks in
individuals based on genetic markers, which allows for identifying individuals at high …

Polygenic risk scores (PRSs) have been widely explored in precision medicine. However,
few studies have thoroughly investigated their best practices in global populations across …

We develop a method, SBayesRC, that integrates genome-wide association study (GWAS)
summary statistics with functional genomic annotations to improve polygenic prediction of …

In complex trait genetics, the ability to predict phenotype from genotype is the ultimate
measure of our understanding of genetic architecture underlying the heritability of a trait. A …

Background: Both lifestyle and genetic factors confer risk for cardiovascular diseases, type 2
diabetes, and dyslipidemia. However, the interactions between these 2 groups of risk factors …

Although the cohort-level accuracy of polygenic risk scores (PRSs)—estimates of genetic
value at the individual level—has been widely assessed, uncertainty in PRSs remains …

A promise of genomics in precision medicine is to provide individualized genetic risk
predictions. Polygenic risk scores (PRS), computed by aggregating effects from many …