A new investigation into the molecular mechanism of andrographolide towards reducing cytokine storm

A Alzahrani - Molecules, 2022 - mdpi.com
Cytokine storm is a condition in which the immune system produces an excessive number of
inflammatory signals, which can result in organ failure and death. It is also known as …

A computational approach identified andrographolide as a potential drug for suppressing COVID-19-induced cytokine storm

M Rehan, F Ahmed, SM Howladar, MY Refai… - Frontiers in …, 2021 - frontiersin.org
Background The newly identified betacoronavirus SARS-CoV-2 is the causative pathogen of
the coronavirus disease of 2019 (COVID-19) that killed more than 3.5 million people till now …

[PDF][PDF] Exploring the mechanisms of cytotoxic and anti-inflammatory property of andrographolide and its derivatives

R Raghavan, S Cheriyamundath… - Pharmacognosy …, 2018 - phcogrev.com
This review explores the mechanisms of cytotoxic and anti‑inflammatory properties of
andrographolide and derivatives of andrographolide in various cell lines. In vitro and in vivo …

Study on the mechanism of andrographolide activation

Q Cai, W Zhang, Y Sun, L Xu, M Wang… - Frontiers in …, 2022 - frontiersin.org
Andrographolide is a natural antibiotic that has the ability to dispel heat, detoxify, reduce
inflammation, and relieve pain. Recent research has shown that it can exert anti …

Andrographolide Induces anti-SARS-CoV-2 Response Through host-directed Mechanism: an in silico Study

BS Das, NC Das, SS Swain, S Mukherjee… - Future …, 2022 - Taylor & Francis
Aim: Considering the present alarming situation of COVID-19 pandemic, we concentrated on
evaluating the efficacy of a novel natural antiviral drug-candidate andrographolide against …

Andrographolide, a natural anti-inflammatory agent: An Update

X Li, W Yuan, J Wu, J Zhen, Q Sun, M Yu - Frontiers in pharmacology, 2022 - frontiersin.org
Botanicals have attracted much attention in the field of anti-inflammatory due to their good
pharmacological activity and efficacy. Andrographis paniculata is a natural plant ingredient …

Andrographolide, an anti-inflammatory multitarget drug: all roads lead to cellular metabolism

RA Burgos, P Alarcón, J Quiroga, C Manosalva… - Molecules, 2020 - mdpi.com
Andrographolide is a labdane diterpene and the main active ingredient isolated from the
herb Andrographis paniculata. Andrographolide possesses diverse biological effects …

Advances in ameliorating inflammatory diseases and cancers by andrographolide: pharmacokinetics, pharmacodynamics, and perspective

J Qu, Q Liu, G You, L Ye, Y Jin, L Kong… - Medicinal Research …, 2022 - Wiley Online Library
Andrographolide, a well‐known natural lactone having a range of pharmacological actions
in traditional Chinese medicine. It has long been used to cure a variety of ailments. In this …

Combination of system biology to probe the anti-viral activity of andrographolide and its derivative against COVID-19

P Khanal, YN Dey, R Patil, R Chikhale, MM Wanjari… - RSC …, 2021 - pubs.rsc.org
The present study aimed to investigate the binding affinity of andrographolide and its
derivative ie, 14-deoxy-11, 12-didehydroandrographolide with targets related to COVID-19 …

Crosstalk between endoplasmic reticulum stress and anti-viral activities: A novel therapeutic target for COVID-19

A Banerjee, SJ Czinn, RJ Reiter, TG Blanchard - Life sciences, 2020 - Elsevier
The outbreak of COVID-19 caused by 2019–nCov/SARS-CoV-2 has become a pandemic
with an urgent need for understanding the mechanisms and identifying a treatment. Viral …