SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model

BL Haagmans, D Noack, NMA Okba… - The Journal of …, 2021 - academic.oup.com
Effective clinical intervention strategies for coronavirus disease 2019 (COVID-19) are
urgently needed. Although several clinical trials have evaluated use of convalescent plasma …

[HTML][HTML] Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection

A Gharbharan, CCE Jordans… - Nature …, 2021 - nature.com
In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care
to treatment with 300mL convalescent plasma containing high titers of neutralizing SARS …

Highly neutralizing COVID-19 convalescent plasmas potently block SARS-CoV-2 replication and pneumonia in Syrian hamsters

Y Takamatsu, M Imai, K Maeda, N Nakajima… - Journal of …, 2022 - Am Soc Microbiol
Despite various attempts to treat severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2)-infected patients with COVID-19 convalescent plasmas, neither appropriate …

[HTML][HTML] Neutralizing monoclonal antibodies for treatment of COVID-19

PC Taylor, AC Adams, MM Hufford… - Nature Reviews …, 2021 - nature.com
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical …

[HTML][HTML] Neutralizing antibodies for the treatment of COVID-19

S Jiang, X Zhang, Y Yang, PJ Hotez, L Du - Nature biomedical …, 2020 - nature.com
Neutralizing antibodies for the treatment of COVID-19 | Nature Biomedical Engineering Skip to
main content Thank you for visiting nature.com. You are using a browser version with limited …

[PDF][PDF] Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models

M Takeshita, H Fukuyama, K Kamada, T Matsumoto… - Iscience, 2022 - cell.com
The use of therapeutic neutralizing antibodies against SARS-CoV-2 infection has been
highly effective. However, there remain few practical antibodies against viruses that are …

[HTML][HTML] Disease severity, fever, age, and sex correlate with SARS-CoV-2 neutralizing antibody responses

S Schlickeiser, T Schwarz, S Steiner, K Wittke… - Frontiers in …, 2021 - frontiersin.org
Clinical trials on the use of COVID-19 convalescent plasma remain inconclusive. While data
on safety is increasingly available, evidence for efficacy is still sparse. Subgroup analyses …

[HTML][HTML] Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma

K Maeda, N Higashi-Kuwata, N Kinoshita, S Kutsuna… - Scientific Reports, 2021 - nature.com
While there are various attempts to administer COVID-19-convalescent plasmas to SARS-
CoV-2-infected patients, neither appropriate approach nor clinical utility has been …

[HTML][HTML] Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in …

KKA Van Rompay, KJ Olstad, RL Sammak… - PLoS …, 2021 - journals.plos.org
There is an urgent need for effective therapeutic interventions against SARS-CoV-2,
including new variants that continue to arise. Neutralizing monoclonal antibodies have …

[PDF][PDF] Comparing SARS-CoV-2 neutralizing antibody levels in convalescent unvaccinated, convalescent vaccinated, and naive vaccinated subjects

L Dulipsingh, EJ Schaefer, D Wakefield, K Williams… - Heliyon, 2023 - cell.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in
December 2019 and spread rapidly. The purpose of this study was to compare neutralizing …