Tendon injuries heal via a scar-mediated response, and there are no biological approaches
to promote more regenerative healing. Mouse flexor tendons heal through the formation of …

Despite the requirement for Scleraxis-lineage (ScxLin) cells during tendon development, the
function of ScxLin cells during adult tendon repair, post-natal growth, and adult homeostasis …

During tendon healing, it is postulated that tendon cells drive tissue regeneration, whereas
extrinsic cells drive pathologic scar formation. Tendon cells are frequently described as a …

Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …

Tendon is a dense connective tissue that transmits high mechanical forces from skeletal
muscle to bone. The transcription factor scleraxis (Scx) is a highly specific marker of both …

To date, the cell and molecular mechanisms regulating tendon healing are poorly
understood. Here, we establish a novel model of tendon regeneration using neonatal mice …

Proper development of tendons is crucial for the integration and function of the
musculoskeletal system. Currently little is known about the molecular mechanisms …

Advances in surgical technique and rehabilitation have transformed zone II flexor tendon
injuries from an inoperable no-man's land to a standard surgical procedure. Despite these …

Tendons are specialized matrix‐rich connective tissues that transmit forces from muscle to
bone and are essential for movement. As tissues that frequently transfer large mechanical …

Tendons resemble connective tissues rich in highly organized collagen fibers, displaying a
remarkably high tensile strength. However, partly due to the low number of tissue-resident …