Parasitic protozoa employ a salvage pathway to synthesize purines and generate essential
active nucleotides, whereas mammals are capable of their de novo biosynthesis. This …

Human African Trypanosomiasis caused by Trypanosoma brucei species is one of the most
damaging neglected tropical diseases. While the number of newly diagnosed cases per …

Trypanosoma brucei parasites cause Human African Trypanosomiasis and the current drugs
for its treatment are often inefficient and toxic. This urges the need to development of new …

Trypanosoma cruzi is the causative pathogen of Chagas disease and the main culprit for
cardiac-related mortality in Latin-America triggered by an infective agent. Incapable of …

ABSTRACT A library of 2, N6-disubstituted adenosine analogs was synthesized and the
analogs were tested for their antiprotozoal activities. It was found that 2-methoxy and 2 …

In this paper, we present the biochemical and biological evaluation of N-arylmethyl-
substituted iminoribitol derivatives as potential chemotherapeutic agents against …

Kinetoplastid parasites are the causative agents of neglected tropical diseases with an
unmet medical need. These parasites are unable to synthesize the purine ring de novo, and …

We describe the design, synthesis and biological evaluation of conformationally-locked 5′-
acyl sulfamoyl adenosine derivatives as new parasitic inhibitors against Trypanosoma and …

Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given
the limited therapeutic options and problems of toxicity and drug resistance, this study …

Sleeping sickness and leishmaniasis are neglected tropical diseases that threaten millions
of people. The currently available therapies present several limitations, including high …