Both rheumatoid arthritis and animal models of autoimmune arthritis are characterized by
hyperactivation of synovial cells and hyperplasia of the synovial membrane. The activated …

Background Rheumatoid arthritis (RA) is an autoimmune disease where the synovial lining
layer of the joint becomes thickened, hypercellular, and highly aggressive. Invading synovial …

We have recently reported that local administration of anti-Fas monoclonal antibody (MAb)
in human T cell leukemia virus type 1 (HTLV-1) carrying mice improved arthritis due to the …

Synovial cells in the rheumatoid synovium show abnormal proliferation, leading to joint
destruction. Rheumatoid synovial cells express functional Fas antigen and are susceptible …

Objective. To examine the expression and function of CD95 (Fas) and its ligand in
rheumatoid arthritis (RA). Methods. We used flow cytometry and reverse transcriptase …

Objective. To examine the expression of Fas/Fas ligand and the role of this ligand/receptor
interaction in the regulation of apoptosis in normal human articular chondrocytes and in …

We previously have demonstrated the ability of primary murine bone marrow-derived DC
(BM-DC), genetically modified by adenoviral infection to express FasL, to inhibit progression …

Previous reports have demonstrated the ability of antigen-presenting cells (APCs),
genetically modified to express Fas ligand (FasL), to inhibit T-cell responses through the …

Fas ligand (FasL) has been shown to mediate both apoptotic and inflammatory reactions. To
rigorously assess the physiological role of different forms of the FasL molecule with regard to …

Objective. To evaluate the efficacy of systemic and intraarticular adenoviral transfer of a
modified tumor necrosis factor α receptor (TNFαR) gene and its expression in rat collagen …