SARS-CoV2 may evade innate immune response, causing uncontrolled neutrophil extracellular traps formation and multi-organ failure

AR Thierry, B Roch - Clinical Science, 2020 - portlandpress.com
We demonstrate that the general clinical conditions, risk factors and numerous pathological
and biological features of COVID-19 are analogous with various disorders caused by the …

COVID-19 hyperinflammation: what about neutrophils?

A Didangelos - MSphere, 2020 - Am Soc Microbiol
ABSTRACT COVID-19 is often related to hyperinflammation that drives lung or multiorgan
injury. The immunopathological mechanisms that cause excessive inflammation are under …

Neutrophils mediate Th17 promotion in COVID-19 patients

Z Parackova, M Bloomfield, A Klocperk… - Journal of Leucocyte …, 2021 - academic.oup.com
From the beginning of 2020, an urgent need to understand the pathophysiology of SARS-
CoV-2 disease (COVID-19), much of which is due to dysbalanced immune responses …

Immunothrombosis in COVID-19: implications of neutrophil extracellular traps

B Bautista-Becerril, R Campi-Caballero… - Biomolecules, 2021 - mdpi.com
SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of
respiratory diseases in recent decades and is the causative agent of the COVID-19 …

On the origin of neutrophil extracellular traps in COVID-19

M Pastorek, M Dúbrava, P Celec - Frontiers in Immunology, 2022 - frontiersin.org
Despite ongoing vaccination COVID-19 is a global healthcare problem because of the lack
of an effective targeted therapy. In severe COVID-19 manifesting as acute respiratory …

Patients with COVID-19: in the dark-NETs of neutrophils

M Ackermann, HJ Anders, R Bilyy, GL Bowlin… - Cell Death & …, 2021 - nature.com
SARS-CoV-2 infection poses a major threat to the lungs and multiple other organs,
occasionally causing death. Until effective vaccines are developed to curb the pandemic, it …

Monocytes and Macrophages in COVID-19

R Knoll, JL Schultze, J Schulte-Schrepping - Frontiers in immunology, 2021 - frontiersin.org
COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …

Elastase and exacerbation of neutrophil innate immunity are involved in multi‐visceral manifestations of COVID‐19

JL Guéant, RM Guéant‐Rodriguez, J Fromonot… - Allergy, 2021 - Wiley Online Library
Background Many arguments suggest that neutrophils could play a prominent role in COVID‐
19. However, the role of key components of neutrophil innate immunity in severe forms of …

Neutrophil extracellular traps and by-products play a key role in COVID-19: pathogenesis, risk factors, and therapy

AR Thierry, B Roch - Journal of clinical medicine, 2020 - mdpi.com
Understanding of the pathogenesis of the coronavirus disease-2019 (COVID-19) remains
incomplete, particularly in respect to the multi-organ dysfunction it may cause. We were the …

[HTML][HTML] A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

L Reyes, MA Sanchez-Garcia, T Morrison… - Wellcome open …, 2021 - ncbi.nlm.nih.gov
Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a
high mortality that is currently in focus given that it is associated with mortality caused by …