Role of inflammatory cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to …

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a severe pandemic of the current century. The vicious …

A neutrophil activation signature predicts critical illness and mortality in COVID-19

ML Meizlish, AB Pine, JD Bishai, G Goshua… - Blood …, 2021 - ashpublications.org
Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-
19, but the mechanisms involved remain poorly understood. We carried out proteomic …

Excessive neutrophils and neutrophil extracellular traps in COVID-19

J Wang, Q Li, Y Yin, Y Zhang, Y Cao, X Lin… - Frontiers in …, 2020 - frontiersin.org
Background: Cases of excessive neutrophil counts in the blood in severe coronavirus
disease (COVID-19) patients have drawn significant attention. Neutrophil infiltration was …

Innate immune deficiencies are associated with severity and poor prognosis in patients with COVID-19

M Peyneau, V Granger, PH Wicky, D Khelifi-Touhami… - Scientific reports, 2022 - nature.com
COVID-19 can cause acute respiratory distress syndrome, leading to death in many
individuals. Evidence of a deleterious role of the innate immune system is accumulating, but …

The interplay between neutrophils, complement, and microthrombi in COVID-19

Y Zuo, Y Kanthi, JS Knight, AHJ Kim - Best practice & research Clinical …, 2021 - Elsevier
As of the end of 2020, coronavirus disease 2019 (COVID-19) remains a global healthcare
challenge with alarming death tolls. In the absence of targeted therapies, supportive care …

The emerging role of neutrophil extracellular traps in severe acute respiratory syndrome coronavirus 2 (COVID-19)

A Arcanjo, J Logullo, CCB Menezes… - Scientific reports, 2020 - nature.com
The novel coronavirus SARS-CoV-2 causes COVID-19, a highly pathogenic viral infection
threatening millions. The majority of the individuals infected are asymptomatic or mildly …

Neutrophil extracellular traps contribute to COVID-19 hyperinflammation and humoral autoimmunity

J Torres-Ruiz, A Absalón-Aguilar, M Nuñez-Aguirre… - Cells, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) is related to enhanced production of NETs, and
autoimmune/autoinflammatory phenomena. We evaluated the proportion of low-density …

The deciphering of the immune cells and marker signature in COVID‐19 pathogenesis: An update

SA Jasim, RS Mahdi, DO Bokov… - Journal of Medical …, 2022 - Wiley Online Library
The precise interaction between the immune system and severe acute respiratory syndrome
coronavirus 2 (SARS‑CoV‑2) is critical in deciphering the pathogenesis of coronavirus …

Tackling the cytokine storm in COVID-19, challenges and hopes

SM Abdin, SM Elgendy, SK Alyammahi, DW Alhamad… - Life Sciences, 2020 - Elsevier
The outbreak of Coronavirus disease 2019 (COVID-19) is the current world health concern,
presenting a public health dilemma with ascending morbidity and mortality rates exceeding …

COVID-19: towards understanding of pathogenesis

W Cao, T Li - Cell research, 2020 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) is spreading rapidly. Although the
cause was quickly identified as a new coronavirus named SARS-CoV-2, our knowledge of …