[HTML][HTML] Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states
LF Schimke, AHC Marques, GC Baiocchi… - Cells, 2022 - mdpi.com
Severe COVID-19 patients present a clinical and laboratory overlap with other
hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH) …
hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH) …
[HTML][HTML] Immune Response and COVID-19: A mirror image of Sepsis
E Lopez-Collazo, J Avendano-Ortiz… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 virus and its associated disease COVID-19 have triggered
significant threats to public health, in addition to political and social changes. An important …
significant threats to public health, in addition to political and social changes. An important …
Metabolic reprograming shapes neutrophil functions in severe COVID‐19
R Borella, S De Biasi, A Paolini… - European Journal of …, 2022 - Wiley Online Library
To better understand the mechanisms at the basis of neutrophil functions during SARS‐CoV‐
2, we studied patients with severe COVID‐19 pneumonia. They had high blood proportion of …
2, we studied patients with severe COVID‐19 pneumonia. They had high blood proportion of …
Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential …
A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
Abstract The COVID-19-, SARS-and MERS-related coronaviruses share many genomic and
structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and …
structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and …
[HTML][HTML] Circulating activated neutrophils in COVID-19: An independent predictor for mechanical ventilation and death
D Dennison, M Al Khabori, S Al Mamari… - International Journal of …, 2021 - Elsevier
Objectives Critical illness in COVID-19 is attributed to an exaggerated host immune
response. Since neutrophils are the major component of innate immunity, we hypothesize …
response. Since neutrophils are the major component of innate immunity, we hypothesize …
[HTML][HTML] Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19
S Mairpady Shambat, A Gomez-Mejia… - PLoS …, 2022 - journals.plos.org
COVID-19 displays diverse disease severities and symptoms including acute systemic
inflammation and hypercytokinemia, with subsequent dysregulation of immune cells …
inflammation and hypercytokinemia, with subsequent dysregulation of immune cells …
The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach
In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …
from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 …
Identification of key signaling pathways induced by SARS-CoV2 that underlie thrombosis and vascular injury in COVID-19 patients
The SARS-CoV-2 pandemic has led to hundreds of thousands of deaths and billions of
dollars in economic damage. The immune response elicited from this virus is poorly …
dollars in economic damage. The immune response elicited from this virus is poorly …
[HTML][HTML] Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patients
Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19)
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …
[HTML][HTML] COVID-19: in the eye of the cytokine storm
R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …