COVID-19 cytokine storm: The anger of inflammation

M Mahmudpour, J Roozbeh, M Keshavarz, S Farrokhi… - Cytokine, 2020 - Elsevier
Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a
state of out-of-control release of a variety of inflammatory cytokines. The molecular …

Vascular occlusion by neutrophil extracellular traps in COVID-19

M Leppkes, J Knopf, E Naschberger, A Lindemann… - …, 2020 - thelancet.com
Background Coronavirus induced disease 2019 (COVID-19) can be complicated by severe
organ damage leading to dysfunction of the lungs and other organs. The processes that …

Neutrophilia and NETopathy as key pathologic drivers of progressive lung impairment in patients with COVID-19

T Narasaraju, BM Tang, M Herrmann… - Frontiers in …, 2020 - frontiersin.org
There is an urgent need for new therapeutic strategies to contain the spread of the novel
coronavirus disease 2019 (COVID-19) and to curtail its most severe complications. Severely …

Cell death in coronavirus infections: Uncovering its role during COVID-19

A Paolini, R Borella, S De Biasi, A Neroni, M Mattioli… - Cells, 2021 - mdpi.com
Cell death mechanisms are crucial to maintain an appropriate environment for the
functionality of healthy cells. However, during viral infections, dysregulation of these …

COVID-19: immunology, immunopathogenesis and potential therapies

A Bhardwaj, L Sapra, C Saini, Z Azam… - International reviews …, 2022 - Taylor & Francis
Abstract The Coronavirus Disease-2019 (COVID-19) imposed public health emergency and
affected millions of people around the globe. As of January 2021, 100 million confirmed …

The immune system and COVID-19: Friend or foe?

F Yazdanpanah, MR Hamblin, N Rezaei - Life sciences, 2020 - Elsevier
Abstract Aim Coronavirus disease 2019 (COVID-19) is a novel highly contagious infection
caused by SARS-CoV-2, which has been became a global public health challenge. The …

Characterization of low-density granulocytes in COVID-19

LE Cabrera, PT Pekkarinen, M Alander… - PLoS …, 2021 - journals.plos.org
Severe COVID-19 is characterized by extensive pulmonary complications, to which host
immune responses are believed to play a role. As the major arm of innate immunity …

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …

[HTML][HTML] Immunopathology of Hyperinflammation in COVID-19

JN Gustine, D Jones - The American journal of pathology, 2021 - Elsevier
The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an unprecedented …

Inflammatory pathways in COVID‐19: mechanism and therapeutic interventions

Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …