Influences of C-reactive protein on the pharmacokinetics of voriconazole in relation to the CYP2C19 genotype: A population pharmacokinetics analysis
L Jing, Y Jiang, N Hu - Frontiers in Pharmacology, 2024 - frontiersin.org
Voriconazole is a broad-spectrum triazole antifungal agent. A number of studies have
revealed that the impact of C-reactive protein (CRP) on voriconazole pharmacokinetics was …
revealed that the impact of C-reactive protein (CRP) on voriconazole pharmacokinetics was …
[HTML][HTML] Influence of C-reactive protein on the pharmacokinetics of voriconazole in relation to the CYP2C19 genotype: a population pharmacokinetics analysis
J Ling, X Yang, L Dong, Y Jiang, S Zou… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Voriconazole is a broad-spectrum triazole antifungal agent. A number of studies have
revealed that the impact of C-reactive protein (CRP) on voriconazole pharmacokinetics was …
revealed that the impact of C-reactive protein (CRP) on voriconazole pharmacokinetics was …
Application of population pharmacokinetic analysis to characterize CYP2C19 mediated metabolic mechanism of voriconazole and support dose optimization
SC Li, SL Wu, WJ Gong, P Cao, X Chen… - Frontiers in …, 2022 - frontiersin.org
Purpose: The aims of this study were to establish a joint population pharmacokinetic model
for voriconazole and its N-oxide metabolite in immunocompromised patients, to determine …
for voriconazole and its N-oxide metabolite in immunocompromised patients, to determine …
Inflammation altered correlation between CYP2C19 genotype and CYP2C19 activity in patients receiving voriconazole
SD Klomp, A Veringa, JWC Alffenaar… - Clinical and …, 2024 - Wiley Online Library
Voriconazole is the cornerstone of the treatment and prevention of fungal infections. While
there is a good correlation between CYP2C19 genotype and voriconazole exposure during …
there is a good correlation between CYP2C19 genotype and voriconazole exposure during …
A personalized CYP2C19 phenotype-guided dosing regimen of voriconazole using a population pharmacokinetic analysis
Highly variable and non-linear pharmacokinetics of voriconazole are mainly caused by
CYP2C19 polymorphisms. This study aimed to develop a mechanistic population …
CYP2C19 polymorphisms. This study aimed to develop a mechanistic population …
Interpersonal factors in the pharmacokinetics and pharmacodynamics of voriconazole: are CYP2C19 genotypes enough for us to make a clinical decision?
X Zhong, X Tong, Y Ju, X Du, Y Li - Current drug metabolism, 2018 - ingentaconnect.com
Background: Invasive mycoses are serious infections with high mortality and increasing
incidence. Voriconazole, an important drug to treat invasive mycosis, is metabolized mainly …
incidence. Voriconazole, an important drug to treat invasive mycosis, is metabolized mainly …
Effects of CYP2C19, CYP2C9 and CYP3A4 gene polymorphisms on plasma voriconazole levels in Chinese pediatric patients
X Fan, H Zhang, Z Wen, X Zheng… - Pharmacogenetics …, 2022 - journals.lww.com
Objectives Voriconazole is the most commonly used antifungal agent in clinical application.
Previous studies suggested that voriconazole was extensively metabolized by CYP450 …
Previous studies suggested that voriconazole was extensively metabolized by CYP450 …
Impact of CYP2C19 Genotype and Drug Interactions on Voriconazole Plasma Concentrations: A Spain Pharmacogenetic‐Pharmacokinetic Prospective Multicenter …
S Blanco‐Dorado, O Maroñas… - … : The Journal of …, 2020 - Wiley Online Library
Background Voriconazole, a first‐line agent for the treatment of invasive fungal infections, is
mainly metabolized by cytochrome P450 (CYP) 2C19. A significant portion of patients fail to …
mainly metabolized by cytochrome P450 (CYP) 2C19. A significant portion of patients fail to …
Individualized treatment with voriconazole in the Chinese population: Inflammation level as a novel marker for dose optimization
X Hao, Y Li, Y Zhang, J Bian, J Zhao… - British Journal of …, 2024 - Wiley Online Library
Aims The aim of this study was to explore the influence and possible mechanisms of
pharmacokinetics‐related gene polymorphisms, especially CYP2C19 polymorphisms, and …
pharmacokinetics‐related gene polymorphisms, especially CYP2C19 polymorphisms, and …
The CYP2C19 ultra-rapid metabolizer genotype influences the pharmacokinetics of voriconazole in healthy male volunteers
G Wang, HP Lei, Z Li, ZR Tan, D Guo, L Fan… - European journal of …, 2009 - Springer
Aim To study the pharmacokinetic characteristics of voriconazole in healthy Chinese male
volunteers in relation to cytochrome P450 (CYP) 2C19 genotype status, including ultra-rapid …
volunteers in relation to cytochrome P450 (CYP) 2C19 genotype status, including ultra-rapid …