[引用][C] P3–452: Controlled discontinuation of antidementive treatment in MCI causes moderate cognitive deterioration

O Peters, L Froelich, I Heuser - Alzheimer's & Dementia, 2006 - Wiley Online Library
Background Mild cognitive impairment (MCI) may represent a preclinical stage of
Alzheimer's disease. Early treatment of MCI may delay the development of dementia …

[HTML][HTML] A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI

O Peters, D Lorenz, A Fesche, K Schmidtke… - The Journal of nutrition …, 2012 - Elsevier
Objectives Mild cognitive impairment (MCI) is etiologically heterogeneous, and a substantial
proportion of MCI subjects will develop different dementia disorders. One subtype of this …

Mild cognitive impairment (MCI): pathogenesis and treatments

I Ha - Clinical Psychopharmacology and Neuroscience, 2009 - cpn.or.kr
Mild cognitive impairment (MCI), poorly defined for many years, has recently been described
as a transition state from healthy cognitive ageing into dementia. This intrinsic heterogeneity …

Mild cognitive impairment: to treat or not to treat

HS Kirshner - Current neurology and neuroscience reports, 2005 - Springer
Mild cognitive impairment (MCI) refers to memory deficits in excess of normal aging, but not
sufficient for the diagnosis of Alzheimer's disease (AD). In general, patients with MCI are not …

Combined treatment with memantine and galantamine‐CR compared with galantamine‐CR only in antidementia drug naïve patients with mild‐to‐moderate …

O Peters, M Fuentes, LK Joachim… - … Research & Clinical …, 2015 - Wiley Online Library
Introduction Several studies have tested the N‐methyl‐D‐aspartate–receptor antagonist
memantine as an add‐on to pre‐existing treatment with acetylcholinesterase inhibitors. The …

Mild cognitive impairment: emerging therapeutics

JJ Sramek, AE Veroff, NR Cutler - Annals of …, 2000 - journals.sagepub.com
OBJECTIVE: To present a general overview of the etiology, definition, and prevalence of
mild cognitive impairment (MCI), as well as outline possible treatment strategies. DATA …

[HTML][HTML] Mild cognitive impairment: searching for the prodrome of Alzheimer's disease

PB Rosenberg, C Lyketsos - World Psychiatry, 2008 - ncbi.nlm.nih.gov
The concept of mild cognitive impairment (MCI) identifies persons who are neither
cognitively normal nor demented. There is increasing evidence that MCI defines a group of …

Clinical trials in mild cognitive impairment: lessons for the future

V Jelic, M Kivipelto, B Winblad - Journal of Neurology, Neurosurgery …, 2006 - jnnp.bmj.com
Mild cognitive impairment (MCI) is an operational definition for a cognitive decline in
individuals with a greater risk of developing dementia. The amnestic subtype of MCI is of …

[引用][C] P4‐356: BENEFITS OF EARLY VERSUS DELAYED MEMANTINE ADDITION TO DONEPEZIL MONOTHERAPY IN PATIENTS WITH MODERATE TO SEVERE …

SM Graham, S Hendrix, V Pejovic… - Alzheimer's & …, 2014 - Wiley Online Library
Background For patients with moderate to severe Alzheimer's disease (AD), treatment
guidelines recommend adding memantine when symptoms of the disease are not well …

[PDF][PDF] P3‐023: Increasing Frailty was Associated with a Greater Chance of Not Attaining Goals in the Vista Clinical Trial of Galantamine

MRH Rockwood, R Schindler, SE Howlett… - Alzheimer's & …, 2016 - researchgate.net
Background: Acetylcholinesterase inhibitor (AChEI) and Memantine are recognized drug
treatments with limited clinical efficacy. Combination therapy for patients with Alzheimer's …