The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin
domain-containing 3 (NLRP3) inflammasome is a member of the NLR family of inherent …

Background Recently, several studies have demonstrated that the NLRP3 inflammasome
participates in detecting cellular damage and mediating inflammatory responses to aseptic …

Inflammation is a devastating pathophysiological process during stroke, a devastating
disease that is the second most common cause of death worldwide. Activation of the NOD …

Stroke is one of the major devastating diseases with no effective medical therapeutics.
Because of the high rate of disability and mortality among stroke patients, new treatments …

Ischemic stroke (also called cerebral ischemia) is one of the leading causes of death and
severe disability worldwide. NLR inflammasomes play a crucial role in sensing cell damage …

Hemorrhagic stroke is a devastating disease with high morbidity and mortality. There is still a
lack of effective therapeutic approach. The recent studies have shown that the innate …

Millions of patients are suffering from ischemic stroke, it is urgent to figure out the
pathogenesis of cerebral ischemia–reperfusion (I/R) injury in order to find an effective cure …

There is a great clinical need to identify the underlying mechanisms, as well as related
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …

Multi-protein complexes, termed “inflammasomes,” are known to contribute to neuronal cell
death and brain injury following ischemic stroke. Ischemic stroke increases the expression …

The NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin
domain-containing 3) inflammasome is a member of the NLR family of innate immune cell …