[PDF][PDF] Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models
JM Gibson, AH Vazquez, K Yamashiro, V Jakkamsetti… - Cell reports, 2023 - cell.com
Cerebellar dysfunction has been linked to autism spectrum disorders (ASDs). Although
cerebellar pathology has been observed in individuals with fragile X syndrome (FXS) and in …
cerebellar pathology has been observed in individuals with fragile X syndrome (FXS) and in …
[PDF][PDF] Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice
Individuals with fragile X syndrome (FXS) are frequently diagnosed with autism spectrum
disorder (ASD), including increased risk for restricted and repetitive behaviors (RRBs) …
disorder (ASD), including increased risk for restricted and repetitive behaviors (RRBs) …
Molecular and cognitive predictors of the continuum of autistic behaviours in fragile X
DZ Loesch, QM Bui, C Dissanayake, S Clifford… - Neuroscience & …, 2007 - Elsevier
The distributions of scores for autistic behaviours obtained from the Autism Diagnostic
Observation Scale—Generic (ADOS-G) were investigated in 147 males and females …
Observation Scale—Generic (ADOS-G) were investigated in 147 males and females …
Deletion of Fmr1 from Forebrain Excitatory Neurons Triggers Abnormal Cellular, EEG, and Behavioral Phenotypes in the Auditory Cortex of a Mouse Model of Fragile …
Fragile X syndrome (FXS) is a leading genetic cause of autism with symptoms that include
sensory processing deficits. In both humans with FXS and a mouse model [Fmr1 knockout …
sensory processing deficits. In both humans with FXS and a mouse model [Fmr1 knockout …
The role of the dorsal striatum in a mouse model for fragile X syndrome: Behavioral and dendritic spine assessment
JL Huebschman, CA Monterrey, DM Foster… - Brain Research, 2022 - Elsevier
Fragile X syndrome (FXS), a leading monogenic cause of autism spectrum disorders
(ASDs), typically occurs as the result of a mutation silencing the Fmr1 gene, preventing …
(ASDs), typically occurs as the result of a mutation silencing the Fmr1 gene, preventing …
The GABAA receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome
Hyperactivity, hypersensitivity to auditory stimuli, and exaggerated fear are common
behavioral abnormalities observed in individuals with fragile X syndrome (FXS), a …
behavioral abnormalities observed in individuals with fragile X syndrome (FXS), a …
[HTML][HTML] Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome
M Kalinowska, MB van der Lei, M Kitiashvili… - Molecular Autism, 2022 - Springer
Abstract Background Fragile X syndrome (FXS), the most common genetic cause of autism
spectrum disorder and intellectual disability, is caused by the lack of fragile X mental …
spectrum disorder and intellectual disability, is caused by the lack of fragile X mental …
[HTML][HTML] Altered frontal connectivity as a mechanism for executive function deficits in fragile X syndrome
Abstract Background Fragile X syndrome (FXS) is the leading inherited monogenic cause of
intellectual disability and autism spectrum disorder. Executive function (EF), necessary for …
intellectual disability and autism spectrum disorder. Executive function (EF), necessary for …
Modelling fragile X syndrome in the laboratory setting: A behavioral perspective
F Melancia, V Trezza - Behavioural Brain Research, 2018 - Elsevier
Fragile X syndrome is the most common form of inherited mental retardation and the most
frequent monogenic cause of syndromic autism spectrum disorders. The syndrome is …
frequent monogenic cause of syndromic autism spectrum disorders. The syndrome is …
[HTML][HTML] Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis
Background Fragile X syndrome and tuberous sclerosis are genetic syndromes that both
have a high rate of comorbidity with autism spectrum disorder (ASD). Several lines of …
have a high rate of comorbidity with autism spectrum disorder (ASD). Several lines of …