Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

The identities of different cells and tissues in multicellular organisms are determined by
tightly controlled transcriptional programs that enable accurate gene expression. The …

Early studies established that transcription initiates within an approximately 50bp DNA
segment capable of nucleating the assembly of RNA polymerase II (Pol II) and associated …

A further twist in the story of eukaryotic transcription appears with the introduction of a class
of transcription factors that may be involved in connecting the “regulatory” transcription …

The RNA polymerase II core promoter is generally defined to be the sequence that directs
the initiation of transcription. This simple definition belies a diverse and complex …

The core promoter is the region in which RNA polymerase II is recruited to the DNA and acts
to initiate transcription, but the extent to which the core promoter sequence determines …

Activation of eukaryotic genes requires a tight temporal control of trans-acting-factor binding
to different types of sequence elements. General transcription factors (GTFs) have a central …

The identification and characterization of mammalian core promoters and transcription start
sites is a prerequisite to understanding how RNA polymerase II transcription is controlled …

The RNA polymerase II core promoter is sometimes referred to as the gateway to
transcription. The core promoter is generally defined to be the stretch of DNA that directs the …

Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II)
transcription system–it is needed for the system to respond to a transcriptional activator …