Background The profound disparity in response to immune checkpoint blockade (ICB) by
cutaneous melanoma (CM) and uveal melanoma (UM) patients is not well understood …

Simple Summary This retrospective multicenter study examines the influence of hepatic and
extrahepatic metastases on the response of immune checkpoint blockade (ICB) in patients …

Background Uveal melanoma (UM) represents the most common primary intra-ocular
malignancy in adults. Up to 50% of the patients develop distant metastases within 10 years …

Uveal melanoma (UM) represents the most common intraocular malignancy in adults and
accounts for about 5% of all melanomas. Primary disease can be effectively controlled by …

Background Immune checkpoint inhibitors (ICI) can lead to long-term responses in patients
with metastatic melanoma. Still many patients with melanoma are intrinsically resistant or …

Uveal (eye) melanoma is the most common primary eye malignancy in adults. Despite
optimal treatments for primary uveal melanoma, up to 50% of patients subsequently develop …

Background The liver is a known site of resistance to immunotherapy and the presence of
liver metastases is associated with shorter progression-free and overall survival (OS) in …

Background While immune checkpoint inhibition (ICI) has revolutionized the treatment of
metastatic cutaneous melanoma, no standard treatments are available for patients with …

Immune checkpoint blockade (ICB) therapy has achieved remarkable clinical benefit in
melanoma. However, our understanding of biomarkers that predict response to ICB …

Background Immune checkpoint inhibitor (ICI) therapy dramatically prolongs melanoma
survival. Currently, the identified ICI markers are sometimes ineffective. The objective of this …