Heart disease and cancer are the two biggest diseases, and obviously the focus of intense
work within the biomedical community. One aspect of this work is the computer simulation of …

This paper discusses the scientific rationale behind the e-Science project, Integrative
Biology, which is developing mathematical modelling tools, HPC-enabled simulations and …

Chaste ('Cancer, heart and soft-tissue environment') is a software library and a set of test
suites for computational simulations in the domain of biology. Current functionality has …

The Integrative Biology project is building a Grid infrastructure which will enable biomedical
scientists to develop accurate multi-scale computational models of the heart and of cancer …

Although it is now feasible to compute multi-cellular models of the heart on a personal
desktop or laptop computer, it is not feasible to undertake the detailed sweeps of high …

Tissue Forge is an open-source interactive environment for particle-based physics,
chemistry and biology modeling and simulation. Tissue Forge allows users to create …

ABSTRACT The IUPS Physiome Project aims to facilitate the understanding of physiological
function in healthy and diseased mammalian tissues by developing a multi-scale modeling …

The BeatBox simulation environment combines flexible script language user interface with
the robust computational tools, in order to setup cardiac electrophysiology in-silico …

E-CELL System is an OpenSource software environment for modeling, simulation and
mathematical analysis of the cell (http://www. e-cell. org/software). Unlike its preceding …

Despite over a century's study, the trigger mechanisms of cardiac arrhythmias are poorly
understood. Even modern experimental methods do not provide sufficient temporal and …