Interleukin 1 (IL 1) is a polypeptide that is produced after infection, injury, or antigenic
challenge. Although the macrophage is a primary source of IL 1, epidermal, epithelial …

Abstract Interleukin-1 (IL-1) represents a family of polypeptides with a wide range of
biological activities. At least two dissimilar gene products have been cloned; there are …

Interleukin-1 (IL-1) is primarily an inflammatory cytokine. Biologically, IL-1 is more closely
related to tumor necrosis factor (TNF) than any other cytokine or interleukin, although the …

The polypeptide cytokine interleukin-1 (IL-1) affects nearly every tissue and organ system. IL-
1 is the prototype of the pro-inflammatory cytokines in that it induces the expression of a …

The interactions between immune and inflammatory cells are mediated in large part by
proteins, termed interleukins (IL), that are able to promote cell growth, differentiation, and …

Interleukin (IL-1) is the term for two polypeptides (IL-1 and IL-1) that possess a wide
spectrum of inflammatory, metabolic, physiologic, hematopoietic, and immunologic …

Ten years ago the cloning of two interleukin‐1 molecules (IL‐1α and IL‐1β) resolved the
question of whether a single polypeptide could evoke a wide variety of biological effects …

The existence of interleukin (IL)-2 has been recognized for over 25 years, and it remains one
of the most extensively studied cytokines. Here we present a broad overview of IL-2 history …

Interleukin-I (IL-1) is the prototypic pro-inflammatory cytokine. There are two forms of IL-1, IL-
1α and IL-Iβ and in most studies, their biological activities are indistinguishable. IL-1 affects …

Interleukin 2 (IL‐2) was one of the first cytokines to be discovered. However, the complex
role of IL‐2 and its receptor in the regulation of immune responses is only now emerging …