Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice
As of June, 2020, more than ten million cases of COVID-19 have been reported worldwide.
The causative pathogen of the disease is a novel coronavirus named severe acute …
The causative pathogen of the disease is a novel coronavirus named severe acute …
[HTML][HTML] Infection of wild-type mice by SARS-CoV-2 B. 1.351 variant indicates a possible novel cross-species transmission route
T Pan, R Chen, X He, Y Yuan, X Deng, R Li… - Signal transduction and …, 2021 - nature.com
COVID-19 is identified as a zoonotic disease caused by SARS-CoV-2, which also can cross-
transmit to many animals but not mice. Genetic modifications of SARS-CoV-2 or mice enable …
transmit to many animals but not mice. Genetic modifications of SARS-CoV-2 or mice enable …
[HTML][HTML] Emerging SARS-CoV-2 variants expand species tropism to murines
Background Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-
CoV-2 variants, including B. 1.1. 7, B. 1.351, P. 1, and P. 3, contain mutations in spike that …
CoV-2 variants, including B. 1.1. 7, B. 1.351, P. 1, and P. 3, contain mutations in spike that …
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion
V Fumagalli, M Ravà, D Marotta, P Di Lucia… - Science …, 2021 - science.org
The development of a tractable small animal model faithfully reproducing human
coronavirus disease 2019 pathogenesis would arguably meet a pressing need in …
coronavirus disease 2019 pathogenesis would arguably meet a pressing need in …
[HTML][HTML] Inactivated SARS-CoV-2 induces acute respiratory distress syndrome in human ACE2-transgenic mice
Z Bi, W Hong, H Que, C He, W Ren, J Yang… - … and Targeted Therapy, 2021 - nature.com
The development of animal models for COVID-19 is essential for basic research and
drug/vaccine screening. Previously reported COVID-19 animal models need to be …
drug/vaccine screening. Previously reported COVID-19 animal models need to be …
[HTML][HTML] Genetically modified mouse models to help fight COVID-19
CB Gurumurthy, RM Quadros, GP Richardson… - Nature protocols, 2020 - nature.com
The research community is in a race to understand the molecular mechanisms of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently …
[HTML][HTML] The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
L Bao, W Deng, B Huang, H Gao, J Liu, L Ren, Q Wei… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus
disease 2019 (COVID-19), which has become a public health emergency of international …
disease 2019 (COVID-19), which has become a public health emergency of international …
[PDF][PDF] Generation of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment
Summary COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with> 4,000,000
confirmed cases worldwide and> 290,000 deaths as of May 15, 2020. It is critical that …
confirmed cases worldwide and> 290,000 deaths as of May 15, 2020. It is critical that …
Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology
SJ Cleary, SC Pitchford, RT Amison… - British journal of …, 2020 - Wiley Online Library
The coronavirus disease 2019 (COVID‐19) pandemic caused by SARS‐CoV‐2 infections
has led to a substantial unmet need for treatments, many of which will require testing in …
has led to a substantial unmet need for treatments, many of which will require testing in …
[PDF][PDF] A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques
The deployment of a vaccine that limits transmission and disease likely will be required to
end the coronavirus disease 2019 (COVID-19) pandemic. We recently described the …
end the coronavirus disease 2019 (COVID-19) pandemic. We recently described the …