Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the
mechanisms underlying this link remain obscure. Using an integrative genomic approach …

Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …

Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …

Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial
proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The …

Insulin resistance underpins the link between obesity and most of its associated metabolic
disorders including type 2 diabetes, fatty liver disease, dyslipidaemia and cardiovascular …

Visceral adipose tissue (VAT)—fat stored around the internal organs—has been suggested
as an independent risk factor for cardiovascular and metabolic disease,–, as well as all …

Type 2 diabetes is a complex metabolic disorder characterized by peripheral insulin
resistance and impaired Β cell function 1, 2. Insulin resistance is inherited as a non …

Common human diseases result from the interplay of many genes and environmental
factors. Therefore, a more integrative biology approach is needed to unravel the complexity …

Reverse causality has made it difficult to establish the causal directions between obesity and
prediabetes and obesity and insulin resistance. To disentangle whether obesity causally …

Metabolic diseases represent a growing threat to world-wide public health. In general, these
disorders result from the interaction of heritable factors with environmental influences. Here …